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Titolo:
EVIDENCE FOR THE CONTRIBUTION OF CCKB RECEPTOR MECHANISMS TO INDIVIDUAL-DIFFERENCES IN AMPHETAMINE-INDUCED LOCOMOTION
Autore:
HIGGINS GA; SILLS TL; TOMKINS DM; SELLERS EM; VACCARINO FJ;
Indirizzi:
UNIV TORONTO,DEPT PSYCHOL,100 ST GEORGE ST TORONTO M5S 1A1 ON CANADA UNIV TORONTO,ADDICT RES FDN TORONTO M5S 1A1 ON CANADA UNIV TORONTO,DEPT PHARMACOL TORONTO M5S 1A1 ON CANADA UNIV TORONTO,DEPT PSYCHOL TORONTO M5S 1A1 ON CANADA UNIV TORONTO,DEPT MED TORONTO M5S 1A1 ON CANADA UNIV TORONTO,DEPT PSYCHIAT TORONTO M5S 1A1 ON CANADA
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 4, volume: 48, anno: 1994,
pagine: 1019 - 1024
SICI:
0091-3057(1994)48:4<1019:EFTCOC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE-MEDIATED BEHAVIORS; NUCLEUS-ACCUMBENS; RAT-BRAIN; CHOLECYSTOKININ RECEPTORS; INDUCED HYPERLOCOMOTION; MOTOR-ACTIVITY; ANTAGONISTS; INJECTION; RELEASE; L-365,260;
Keywords:
AMPHETAMINE; LOCOMOTION; CHOLECYSTOKININ; ANTAGONISTS; DEVAZEPIDE; L365-260; INDIVIDUAL DIFFERENCES; RAT;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
G.A. Higgins et al., "EVIDENCE FOR THE CONTRIBUTION OF CCKB RECEPTOR MECHANISMS TO INDIVIDUAL-DIFFERENCES IN AMPHETAMINE-INDUCED LOCOMOTION", Pharmacology, biochemistry and behavior, 48(4), 1994, pp. 1019-1024

Abstract

Recent evidence shows that rats exhibit individual differences in their locomotor response to amphetamine (AMP). Moreover, evidence has accumulated showing that high-AMP responders exhibit more mesolimbic dopaminergic (DAergic) activation in response to AMP treatment than low-AMP responders. Cholecystokinin (CCK) is a peptide that is colocalised with mesolimbic DA and exerts complex modulatory actions on DA function. Two CCK receptor subtypes have been identified and selective antagonists have been developed. To examine the possible contribution of endogenous CCK mechanisms to individual differences in responsivity to AMPtreatment, male Wistar rats were divided into low- and high-AMP responders based on a median split of their locomotor response to AMP and the effects of the selective CCK antagonists L365-260 (CCKB; 0.01, 0.1,0.5 mg/kg; n = 16) and devazepide (CCKA; 0.001, 0.01, 0.1 mg/kg; n = 23) were determined. Results showed that L365-260 (0.1 mg/kg) potentiated AMP-induced hyperactivity in low-AMP responders but did not affectAMP-induced hyperactivity in high-AMP responders. Devazepide was without effect in both groups of animals. This pattern of results suggeststhat CCKB, but not CCKA, receptor mechanisms contribute to interindividual variation in responsivity to AMP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 10:13:23