Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
STOPPING WHEN THE EXPERIMENTAL REGIMEN DOES NOT APPEAR TO HELP
Autore:
WIEAND S; SCHROEDER G; OFALLON JR;
Indirizzi:
MAYO CLIN & MAYO FDN,PLUMMER 4 ROCHESTER MN 55905
Titolo Testata:
Statistics in medicine
fascicolo: 13-14, volume: 13, anno: 1994,
pagine: 1453 - 1458
SICI:
0277-6715(1994)13:13-14<1453:SWTERD>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLINICAL-TRIALS; PHASE-III; DESIGN; POWER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
CompuMath Citation Index
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
S. Wieand et al., "STOPPING WHEN THE EXPERIMENTAL REGIMEN DOES NOT APPEAR TO HELP", Statistics in medicine, 13(13-14), 1994, pp. 1453-1458

Abstract

We discuss a procedure that offers the possibility of reducing the number of patients assigned to experimental regimens which are no more effective than a standard regimen. The procedure is useful in advanced cancer trials in which the length of the accrual period might be more than twice the median survival time for the standard regimen. The procedure is intuitively appealing and offers a 50 per cent chance of stopping accrual to ineffective therapies, yet is associated with a loss of power of less than 0.02.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 07:24:00