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Titolo:
SERUM INCREASE AND LIVER OVEREXPRESSION OF CARBOHYDRATE 19.9-ANTIGEN IN PATIENTS WITH GENETIC HEMOCHROMATOSIS
Autore:
DEUGNIER YM; RABOT AF; GUYADER D; MOIRAND R; TURLIN B; BOUCHER E; LEBERT P; BRISSOT P;
Indirizzi:
CTR HOSP REG & UNIV PONTCHAILLOU,MALAD FOIE CLIN,RUE HENRI GUILLOUX F-35033 RENNES FRANCE CTR HOSP REG & UNIV PONTCHAILLOU,INSERM,U49 RENNES FRANCE CTR HOSP REG & UNIV PONTCHAILLOU,ANAT & CYTOL PATHOL LAB RENNES FRANCE CTR HOSP REG & UNIV PONTCHAILLOU,HORMON ENZYMOL LAB RENNES FRANCE
Titolo Testata:
Gut
fascicolo: 8, volume: 35, anno: 1994,
pagine: 1107 - 1111
SICI:
0017-5749(1994)35:8<1107:SIALOO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER-ASSOCIATED ANTIGEN; TUMOR-MARKERS CA-19-9; HEPATIC IRON INDEX; CARCINOEMBRYONIC ANTIGEN; PANCREATIC-CANCER; DESIALYLATED GLYCOPROTEINS; GASTROINTESTINAL CANCER; DISEASES; HEMOCHROMATOSIS; CARCINOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
Y.M. Deugnier et al., "SERUM INCREASE AND LIVER OVEREXPRESSION OF CARBOHYDRATE 19.9-ANTIGEN IN PATIENTS WITH GENETIC HEMOCHROMATOSIS", Gut, 35(8), 1994, pp. 1107-1111

Abstract

CA 19.9 antigen is mainly secreted by biliary and pancreatic duct cells. Its metabolism could be modified in genetic haemochromatosis by iron accumulation within these cells. Therefore, CA 19.9 was assayed in the serum samples of 84 patients with genetic haemochromatosis before and after iron depletion and immunolocalised in the liver of 24 untreated genetic haemochromatosis cases. The study showed that serum CA 19.9 (N<37 IU/1) was increased (SD) before treatment (41.2 (34)) when compared with after the venesection period (16 (12)), and correlated, before treatment, with the amount of iron excess, transaminases, fibrosis, and biliary iron deposits. Hepatic CA 19.9 was located within the cytoplasm of bile duct and cholangiolar cells. In conclusion, this studyshows that a mild, reversible, and non-specific increase in serum CA 19.9 is common in genetic haemochromatosis patients and shows that this increase is related to iron excess, directly or through associated liver damage. The unexplained finding of a mild increase in serum CA 19.9 should lead, in a patient with no diagnosis, to the search for liver iron overload, and, in a patient with untreated genetic haemochromatosis, not to further diagnostic procedures unless this finding persists after completion of the venesection treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:21:26