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Titolo:
HIGH-RESOLUTION PET IMAGING AND QUANTITATION OF PHARMACEUTICAL BIODISTRIBUTIONS IN A SMALL ANIMAL USING AVALANCHE PHOTODIODE DETECTORS
Autore:
MARRIOTT CJ; CADORETTE JE; LECOMTE R; SCASNAR V; ROUSSEAU J; VANLIER JE;
Indirizzi:
UNIV SHERBROOKE,FAC MED,DEPT MED NUCL & RADIOBIOL SHERBROOKE J1H 5N4 PQ CANADA UNIV SHERBROOKE,FAC MED,DEPT MED NUCL & RADIOBIOL SHERBROOKE J1H 5N4 PQ CANADA
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 8, volume: 35, anno: 1994,
pagine: 1390 - 1396
SICI:
0161-5505(1994)35:8<1390:HPIAQO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION TOMOGRAPHY; TUMOR UPTAKE; BIOLOGICAL-ACTIVITIES; PHOTODYNAMIC THERAPY; TISSUE DISTRIBUTION; C3H MICE; SPECT; PHTHALOCYANINES; RATS;
Keywords:
PET IMAGING; BIODISTRIBUTION; PHOTODIODE DETECTORS; LABORATORY ANIMALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
C.J. Marriott et al., "HIGH-RESOLUTION PET IMAGING AND QUANTITATION OF PHARMACEUTICAL BIODISTRIBUTIONS IN A SMALL ANIMAL USING AVALANCHE PHOTODIODE DETECTORS", The Journal of nuclear medicine, 35(8), 1994, pp. 1390-1396

Abstract

The feasibility of high-resolution PET using BGO-avalanche photodiodedetectors for in vivo imaging and quantitation of the biodistributionof radiopharmaceuticals in smalt animals is demonstrated. A prototypePET camera consisting of two scanning arrays of eight EG&G C30994 solid-state scintillation detectors was used to simulate a 310-mm diameter dual-ring animal tomograph having a 130-mm port and three imaging slices, each about 3.5 mm thick. The spatial resolution (FWHM) is 3 mm or less, isotropic and uniform throughout the 120-mm diameter field of view. Methods: Female Fischer 344/CRBL rats implanted with subcutaneous mammary adenocarcinoma tumors were injected with copper-tetrasulfophthalocyanine (CuPcS(4)), a potential sensitizer for the photodynamic therapy of cancer, labeled with (CU)-C-64 (T-1/2 = 12.7 hr, beta(+):19%). Results: In spite of the low specific radioactivity of Cu-64 and other inherent limitations, organs such as the liver, kidneys and the tumor could be resolved with sufficient detail for their separation and quantitation. Apart from the tumor, agreement was obtained between thebiodistributions measured by PET and by scintillation counting. The discrepancy for the tumor measurement results from averaging the radioactivity over the entire tumor volume when, in fact, CuPcS(4) does not completely penetrate the tumor. This incomplete penetration is noted on the PET images. Conclusions: PET based an avalanche photodiode detectors provides an accurate measurement of target organ and tumor tissueconcentrations. These preliminary results demonstrate the potential of very high resolution PET for biodistribution studies in small animals.

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Documento generato il 25/01/21 alle ore 14:33:11