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Titolo:
AUTOREGULATION OF THE HUMAN WT1 GENE PROMOTER
Autore:
MALIK KTA; POIRIER V; IVINS SM; BROWN KW;
Indirizzi:
UNIV BRISTOL,SCH MED SCI,DEPT PATHOL & MICROBIOL,CLIC RES UNIT,UNIV WALK BRISTOL BS8 1TD AVON ENGLAND
Titolo Testata:
FEBS letters
fascicolo: 1, volume: 349, anno: 1994,
pagine: 75 - 78
SICI:
0014-5793(1994)349:1<75:AOTHWG>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
WILMS-TUMOR LOCUS; FACTOR-A-CHAIN; SUPPRESSOR WT1; DELETION; PRODUCT; 11P13; BINDING; TRANSCRIPTION; ASSOCIATION; REPRESSION;
Keywords:
WILMS TUMOR GENE; PROMOTER REGULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
K.T.A. Malik et al., "AUTOREGULATION OF THE HUMAN WT1 GENE PROMOTER", FEBS letters, 349(1), 1994, pp. 75-78

Abstract

The human Wilms tumour suppressor gene, WT1, encodes a zinc-finger protein which can function as a transcriptional activator or suppressor. This study reports the analysis of the human WT1 gene promoter, and demonstrates that high levels of WT1 expression lead to autosuppressionof the WT1 promoter. Deletion analyses of the promoter region implicate sequences 5' and 3' of the transcriptional start site as being crucial in WT1 autosuppression. Loss or alteration of this function of WT1may be important in tumourigenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 19:22:24