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Titolo:
RAPID, REVERSIBLE ELIMINATION OF MEDIAL OLIVOCOCHLEAR EFFERENT FUNCTION FOLLOWING SINGLE INJECTIONS OF GENTAMICIN IN THE GUINEA-PIG
Autore:
SMITH DW; ERRE JP; ARAN JM;
Indirizzi:
DUKE UNIV,MED CTR,DIV OTOLARYNGOL HEAD & NECK SURG,BOX 3550 DURHAM NC27710 UNIV BORDEAUX 2,AUDIO EXPTL LAB,INSERM,U229 F-33076 BORDEAUX FRANCE
Titolo Testata:
Brain research
fascicolo: 2, volume: 652, anno: 1994,
pagine: 243 - 248
SICI:
0006-8993(1994)652:2<243:RREOMO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
COCHLEAR HAIR-CELLS; CONTRALATERAL SOUND; ANTIBIOTICS; PHARMACOKINETICS; POTENTIALS; KINETICS; NEOMYCIN; CHANNEL; RAT;
Keywords:
AMINOGLYCOSIDE ANTIBIOTIC; GENTAMICIN; OLIVOCOCHLEAR EFFERENT; CONTRALATERAL EFFERENT SUPPRESSION; COMPOUND ACTION POTENTIAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
D.W. Smith et al., "RAPID, REVERSIBLE ELIMINATION OF MEDIAL OLIVOCOCHLEAR EFFERENT FUNCTION FOLLOWING SINGLE INJECTIONS OF GENTAMICIN IN THE GUINEA-PIG", Brain research, 652(2), 1994, pp. 243-248

Abstract

Measurements were made of the ability of nonsimultaneous, contralaterally presented broadband noise maskers to suppress ipsilaterally-evoked compound action potentials (CAPs) of the auditory nerve to 8-kHz tone pips in guinea pigs. Contralateral acoustic stimuli have been shown to suppress responses to ipsilateral stimuli through the action of themedial olivocochlear efferent bundle. In this study, maximum suppression across subjects ranged from 2-6 dB. The ability of the contralateral noise to suppress ipsilateral CAPs was rapidly reduced beginning within minutes of a single intramuscular injection of the aminoglycosideantibiotic gentamicin (150 mg/kg), and, in general, was completely abolished by 1.5-2 h. Changes in suppression were presumably produced bygentamicin-induced blockade of presynaptic calcium channels on the medial olivocochlear efferents and closely follow the pharmacokinetics of gentamicin in perilymph. Reductions in efferent-mediated suppressionwere observed in the absence of any measurable change in either CAP thresholds to different frequencies or CAP input/output. Suppression was partially restored in some animals after 24 h, and was fully recovered in all subjects within 96 h postinjection. The present studies suggest that measures of efferent function might form the rational basis for an objective means to assess aminoglycoside insult on the cochlea in the absence of hair cell damage. These results also indicate that single injections of gentamicin offer a reversible, non-invasive model in which medial efferent function can be studied in behavioral animals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:29:54