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Titolo:
APPLICATION OF THE ZERO-CROSSING DERIVATIVE SPECTROPHOTOMETRY TO THE DETERMINATION OF CEPHRADINE AND CLAVULANIC ACID IN BINARY-MIXTURES
Autore:
MURILLO JA; LEMUS JM; GARCIA LF;
Indirizzi:
UNIV CASTILLA LA MANCHA,DEPT ANALYT CHEM & FOOD TECHNOL E-13071 CIUDAD REAL SPAIN
Titolo Testata:
Analytical letters
fascicolo: 10, volume: 27, anno: 1994,
pagine: 1875 - 1892
SICI:
0003-2719(1994)27:10<1875:AOTZDS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PURE FORM; CEPHALOSPORINS; SPECTROMETRY;
Keywords:
CEPHRADINE; CLAVULANIC ACID; BETA-LACTAMIC ANTIBIOTIC; FIRST DERIVATIVE SPECTROPHOTOMETRY; SIMULTANEOUS DETERMINATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Murillo et al., "APPLICATION OF THE ZERO-CROSSING DERIVATIVE SPECTROPHOTOMETRY TO THE DETERMINATION OF CEPHRADINE AND CLAVULANIC ACID IN BINARY-MIXTURES", Analytical letters, 27(10), 1994, pp. 1875-1892

Abstract

Derivative spectrophotometry, on the basis of the zero-crossing measurements in the first derivative spectra, is used for the resolution ofthe binary mixtures of cephradine (CED) and clavulanic acid (CA). Neither sample pretreatment nor any separation step were required. Linearcalibration graphs of first derivative values at 277.0 and 235.5 nm for cephradine and clavulanic acid, respectively, with negligible intercept on the y-axis were obtained versus concentration in the range of 2.0-56.0 mu g mL(-1) for cephradine and 2.0-28.0 mu g mL(-1) for clavulanic acid. The detection limits for cephradine and clavulanic acid ata 0.05 level of significance, were 0.16 and 0.17 mu g mL(-1), respectively. The proposed method has been applied to determine these drugs in mixtures. Injectable dosages forms of cephradine and standard clavulanic acid were mixed and determined in saline physiological serum and physiological serum containing glucose.

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Documento generato il 27/11/20 alle ore 16:09:41