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Titolo:
PRONOSTIC VALUE OF BETA-2-MICROGLOBULIN I N YOUNG-ADULTS WITH HODGKINS-DISEASE
Autore:
FLEURY J; TORTOCHAUX J; LEGROS M; CURE H; KWIATKOWSKI F; FERRIERE JP; TRAVADE P; DIONET C; GAILLARD G; CHASSAGNE J; BIGNON YJ; VANPRAAGH I; BELEMBAOGO E; CHOLLET P; PLAGNE R;
Indirizzi:
CTR JEAN PERRIN,58 RUE MONTALEMBERT,BP 392 F-63011 CLERMONT FERRAND FRANCE
Titolo Testata:
Bulletin du cancer
fascicolo: 7, volume: 81, anno: 1994,
pagine: 625 - 631
SICI:
0007-4551(1994)81:7<625:PVOBIN>2.0.ZU;2-L
Fonte:
ISI
Lingua:
FRE
Soggetto:
LARGE-CELL LYMPHOMAS; CLASS-I; PROGNOSTIC FACTORS; SERUM BETA-2-MICROGLOBULIN; BETA-2 MICROGLOBULIN; ANTIGEN EXPRESSION; HLA EXPRESSION; HEAVY-CHAINS; ASSOCIATION; CHEMOTHERAPY;
Keywords:
BETA-2-MICROGLOBULIN; HODGKINS DISEASE; PROGNOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
J. Fleury et al., "PRONOSTIC VALUE OF BETA-2-MICROGLOBULIN I N YOUNG-ADULTS WITH HODGKINS-DISEASE", Bulletin du cancer, 81(7), 1994, pp. 625-631

Abstract

From 1977 to 1989, we measured serum beta-2-microglobulin (beta2-MG) levels from 64 unselected and untreated patients, between 18 to 50-year-old, affected by Hodgkin's disease. Serum beta2-MG level was measured by radioimmunoassay (Phadebas beta2 microtest). Then, all patients received a chemotherapy such as MOPP or alternating MOPP/ABVD followed or not by radiotherapy. Elevated serum beta2-MG level (> 2.4 mg/l) is associated with advanced stage disease (stage III-IV), presence of systemic symptoms and bulky tumor. Nevertheless, a multivariate analysis shows that the serum beta2-MG level is the most significant prognosticindicator for disease free survival. The prognostic value of serum beta2-MG is demonstrated for myeloma and non Hodgkin's lymphoma. A few authors have evaluated the prognostic impact of serum beta2-MG in Hodgkin's disease. This study requires confirmation by multicentric and prospective trial.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 03:46:25