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Titolo:
INTERACTION OF BASIC FIBROBLAST GROWTH-FACTOR (FGF-2) WITH NONRESPONSIVE HELA-CELLS
Autore:
GANNOUNZAKI L; PIERI I; BADET J; BARRITAULT D;
Indirizzi:
UNIV PARIS 12,LAB CRRET,INSERM,CJF 9014,AVE GEN GAULLE F-94010 CRETEIL FRANCE UNIV PARIS 12,LAB CRRET,INSERM,CJF 9014 F-94010 CRETEIL FRANCE
Titolo Testata:
Experimental cell research
fascicolo: 2, volume: 213, anno: 1994,
pagine: 375 - 382
SICI:
0014-4827(1994)213:2<375:IOBFG(>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR PRODUCTION; HEPARAN-SULFATE; EXTRACELLULAR-MATRIX; ENDOTHELIAL-CELLS; PROTEOLYTIC DEGRADATION; FACTOR RECEPTOR; FACTOR-I; BINDING; INTERNALIZATION; AFFINITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
L. Gannounzaki et al., "INTERACTION OF BASIC FIBROBLAST GROWTH-FACTOR (FGF-2) WITH NONRESPONSIVE HELA-CELLS", Experimental cell research, 213(2), 1994, pp. 375-382

Abstract

Human HeLa adenocarcinoma cells did not respond to basic fibroblast growth factor (bFGF or FGF-2) but did bind the same amount of bFGF as responsive Chinese hamster lung fibroblasts (CCL 39). Heparitinase II treatment of HeLa and CCL 39 cells resulted in a decrease of bFGF binding by 96 and 57%, respectively, indicating that heparan sulfate molecules were involved in bFGF binding. On HeLa cells, bFGF bound to a single family of low-affinity sites. Cross-linking experiments of I-125-bFGF to HeLa cells yielded several labeled complexes. Cell-associated (125)-bFGF Was internalized in both cell types either by high-affinity receptors and heparitinase-sensitive sites in CCL 39 cells or by heparitinase-sensitive binding sites only in HeLa cells. The binding of bFGFto nonresponsive HeLa cells and its internalization via a family of heparitinase-sensitive binding sites might illustrate other functions of bFGF unrelated to cell proliferation. (C) 1994 Academic Press,Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:08:51