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Titolo:
SELF-ADMINISTERED NICOTINE ACTIVATES THE MESOLIMBIC DOPAMINE SYSTEM THROUGH THE VENTRAL TEGMENTAL AREA
Autore:
CORRIGALL WA; COEN KM; ADAMSON KL;
Indirizzi:
ADDICT RES FDN,33 RUSSELL ST TORONTO M5S 2S1 ON CANADA UNIV TORONTO,DEPT PHYSIOL TORONTO ON CANADA
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 653, anno: 1994,
pagine: 278 - 284
SICI:
0006-8993(1994)653:1-2<278:SNATMD>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTANTIA NIGRA NEURONS; CENTRAL NERVOUS-SYSTEM; NUCLEUS-ACCUMBENS; PEDUNCULOPONTINE NUCLEUS; IMMUNOHISTOCHEMICAL LOCALIZATION; LOCOMOTOR-ACTIVITY; LIMBIC SYSTEM; RAT; BRAIN; RECEPTORS;
Keywords:
NICOTINE; MESOLIMBIC DOPAMINE; PEDUNCULOPONTINE TEGMENTAL NUCLEUS; CHOLINERGIC; REINFORCEMENT; DIHYDRO-BETA-ERYTHROIDINE; COCAINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
W.A. Corrigall et al., "SELF-ADMINISTERED NICOTINE ACTIVATES THE MESOLIMBIC DOPAMINE SYSTEM THROUGH THE VENTRAL TEGMENTAL AREA", Brain research, 653(1-2), 1994, pp. 278-284

Abstract

Microinfusions of the nicotinic antagonist dihydro-beta-erythroidine (DH beta E) were used to examine the role of the mesolimbic dopamine system in nicotine reinforcement in rats. Infusions of DH beta E into the ventral tegmental area (VTA) prior to the start of i.v. nicotine self-administration sessions resulted in a significant decrease in the number of nicotine infusions voluntarily obtained. In contrast, the same doses of DH beta E infused into the nucleus accumbens were without effect on nicotine self-administration The reductions caused by DH betaE were specific to nicotine reinforcement; neither operant respondingmaintained by food, cocaine self-administration, or spontaneous locomotor activity were altered by local applications of DH beta E within the VTA. The reduction in nicotine self-administration following treatment in the VTA was also specific to the nicotinic antagonist, and was not duplicated by infusions of the muscarinic antagonist atropine. Partial lesions of the pedunculopontine tegmental nucleus, the likely origin of cholinergic fibers to the VTA, were without effect on nicotine self-administration, suggesting that the effects of DH beta E were notdue to disruption of a tonically active cholinergic input to the VTA from this source. These data show that nicotine acts within the VTA region to initiate processes which are critical to the reinforcing properties of the drug.

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Documento generato il 08/08/20 alle ore 07:30:01