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Titolo:
PARTICIPATION OF NORADRENERGIC NEUROTRANSMISSION IN THE SUPPRESSION BY SUBSTANCE-P OF ALPHA(2)-ADRENOCEPTORS AT THE NUCLEUS-RETICULARIS GIGANTOCELLULARIS INVOLVED IN CENTRAL CARDIOVASCULAR REGULATION IN THE RAT
Autore:
TSOU MY; LEN WB; LEE TY; CHAN SHH; PAN WHT; CHAN JYH;
Indirizzi:
VET GEN HOSP,DEPT MED RES TAIPEI 11217 TAIWAN VET GEN HOSP,DEPT MED RES TAIPEI 11217 TAIWAN VET GEN HOSP,DEPT ANESTHESIOL TAIPEI 11217 TAIWAN NATL YANG MING MED COLL,INST PHARMACOL TAIPEI 11221 TAIWAN
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 653, anno: 1994,
pagine: 183 - 190
SICI:
0006-8993(1994)653:1-2<183:PONNIT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL NERVOUS-SYSTEM; MEDULLA-OBLONGATA; IMMUNOREACTIVE NEURONS; NOREPINEPHRINE RELEASE; VENTROLATERAL MEDULLA; BARORECEPTOR REFLEX; ANGIOTENSIN-III; CELL BODIES; GUANABENZ; CLONIDINE;
Keywords:
SUBSTANCE P; NOREPINEPHRINE; ALPHA(2)-ADRENOCEPTOR; GUANABENZ; NUCLEUS RETICULARIS GIGANTOCELLULARIS; MICRODIALYSIS; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
M.Y. Tsou et al., "PARTICIPATION OF NORADRENERGIC NEUROTRANSMISSION IN THE SUPPRESSION BY SUBSTANCE-P OF ALPHA(2)-ADRENOCEPTORS AT THE NUCLEUS-RETICULARIS GIGANTOCELLULARIS INVOLVED IN CENTRAL CARDIOVASCULAR REGULATION IN THE RAT", Brain research, 653(1-2), 1994, pp. 183-190

Abstract

We applied reverse microdialysis and HPLC analysis to quantify the participation of noradrenergic neurotransmission in the modulation by substance P of alpha(2)-adrenoceptors at the nucleus reticularis gigantocellularis involved in cardiovascular regulation, using Sprague-Dawleyrats anesthetized with pentobarbital sodium. The efficacy of circulatory suppression of a centrally acting alpha(2)-adrenoceptor agonist, guanabenz, was used as the experimental index. Continuous infusion of substance P (600 or 1200 pmol/mu l/min) into the nucleus reticularis gigantocellularis through a stereotaxically positioned microdialysis probe (active exchange length: 500 mu m, diameter: 220 mu m) for 80 min elicited a reduction in the hypotensive and bradycardiac actions of guanabenz (100 mu g/kg, i.v.). This implied suppression of alpha(2)-adrenoceptor activity correlated positively with the time-course of increase in the estimated extracellular concentration of the undecapeptide and norepinephrine in the nucleus reticularis gigantocellularis. Experimentally elevating the concentration of norepinephrine at this reticular nucleus via microinfusion by reverse microdialysis also decreased the efficacy of the cardiovascular suppression of the aminoguanidine compound. These results suggest that substance P may depress the activityof the alpha(2)-adrenoceptors in the nucleus reticularis gigantocellularis that are involved in central cardiovascular regulation via an increase in the extracellular concentration of norepinephrine at this reticular nucleus.

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Documento generato il 26/09/20 alle ore 05:15:43