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Titolo:
NEUROBIOLOGY OF OPIOID-PEPTIDES
Autore:
ASAI M; GUTIERREZ R;
Indirizzi:
INST MEXICANO PSQUIATRIA,ANAL QUIM LAB,CALZ MEXICO XOCHIMILCO 101 SANLORENZO 14370 DF MEXICO INST MEXICANO PSQUIATRIA,DIV NEUROCIENCIAS,NEUROFISIOL LAB SAN LORENZO 14370 DF MEXICO
Titolo Testata:
Salud mental
fascicolo: 2, volume: 17, anno: 1994,
pagine: 30 - 43
SICI:
0185-3325(1994)17:2<30:NOO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
SPA
Soggetto:
MULTIPLE OPIATE RECEPTORS; CHRONIC SPINAL DOG; ENKEPHALIN-CONTAINING PEPTIDES; BETA-LIPOTROPIN PRECURSOR; PHENCYCLIDINE-LIKE DRUGS; NALORPHINE-LIKE DRUGS; ACTS LIKE MORPHINE; RAT-BRAIN; ENDOGENOUS OPIOIDS; SYNAPTIC-MEMBRANES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social Sciences Citation Index
Citazioni:
109
Recensione:
Indirizzi per estratti:
Citazione:
M. Asai e R. Gutierrez, "NEUROBIOLOGY OF OPIOID-PEPTIDES", Salud mental, 17(2), 1994, pp. 30-43

Abstract

During the last 25 years we have attended to the formation of new andimportant fields in the neuroscience domain. Due to the study of neuropeptides. Virtually, the neuropeptides represent a new class of chemical transmitters, many of wich could act as endocrine, amacrine or paracrine hormones. In addition, the neuropeptides were also found to influence other higher functions, including cognition and memory. The biochemical diversity in neurons has revealed the coexistence, in the same neurons, of classical small transmitters with neuropeptides. This finding offers new and promisory perspectives in the synaptic transmission. At this time, the largest group in the neuropeptide families couldbe that of the opioid peptides. Endorphins could be the best studied and characterized group, because of their implications in the narcoticmechanisms of action and treatment of pain. In this work, we recalledbriefly the historical background of the discovery of enkephalins andwe reviewed the biochemical characteristics implicated in the opioid peptide metabolism: the biosynthesis, release, catabolism and receptorbinding. We also analyzed updated data concerning the opioid peptide physiology. The accumulated knowledge of two decades of study of biochemistry, pharmacology, physiology and the distribution of the opioid peptides, together with the molecular biology technics and the modern clinical diagnostic technology, such as the positron emission tomography and the nuclear magnetic resonance, promise new perspectives and possibilities of therapeutical intervention.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 10:03:51