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Titolo:
CORRELATION BETWEEN IN-VITRO AND IN-VIVO ACTIVITY OF ANTIFUNGAL AGENTS AGAINST CANDIDA SPECIES
Autore:
ANAISSIE EJ; KARYOTAKIS NC; HACHEM R; DIGNANI MC; REX JH; PAETZNICK V;
Indirizzi:
UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT MED SPECIALTIES,INFECT DIS SECT,1515 HOLCOMBE BLVD,BOX 47 HOUSTON TX 77030 UNIV TEXAS,SCH MED,DEPT INTERNAL MED HOUSTON TX 00000
Titolo Testata:
The Journal of infectious diseases
fascicolo: 2, volume: 170, anno: 1994,
pagine: 384 - 389
SICI:
0022-1899(1994)170:2<384:CBIAIA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMPHOTERICIN-B; SUSCEPTIBILITY TEST; CRYPTOCOCCAL MENINGITIS; FUNGAL-INFECTIONS; FLUCONAZOLE; ALBICANS; INVIVO; INVITRO; MODEL; KETOCONAZOLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
E.J. Anaissie et al., "CORRELATION BETWEEN IN-VITRO AND IN-VIVO ACTIVITY OF ANTIFUNGAL AGENTS AGAINST CANDIDA SPECIES", The Journal of infectious diseases, 170(2), 1994, pp. 384-389

Abstract

The correlation between antifungal susceptibility testing and in vivoresponse to antifungal therapy was examined in experimental murine candidiasis. In vitro susceptibility testing was done using a microbrothdilution method. Twenty-two Candida albicans, 4 Candida lusitaniae, and 2 Candida krusei isolates were tested against fluconazole, flucytosine, and amphotericin B. In vivo antifungal activity was tested in murine hematogenous candidiasis. Normal CF1 mice were infected with each of the C. albicans strains; immunosuppressed CF1 mice were inoculated with C. lusitaniae or C. krusei. Mice received various doses of antifungal agents, and survival was monitored for 21 days. Kidney fungal burden was examined on day 4. Antifungal therapy significantly prolonged survival and reduced tissue counts in animals infected with organisms susceptible to the agent tested (P < .05). In vitro resistance to a drug predicted its lack of in vivo activity. These results appear to correlate well with outcome of murine hematogenous candidiasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 10:36:21