Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFECT OF CYCLOSPORINE-A ON GLOMERULAR-FILTRATION RATE IN CHILDREN WITH MINIMAL CHANGE NEPHROTIC SYNDROME
Autore:
HULTON SA; JADRESIC L; SHAH V; TROMPETER RS; DILLON MJ; BARRATT TM;
Indirizzi:
CHILDRENS HOSP,DEPT NEPHROL BIRMINGHAM B16 8ET W MIDLANDS ENGLAND
Titolo Testata:
Pediatric nephrology
fascicolo: 4, volume: 8, anno: 1994,
pagine: 404 - 407
SICI:
0931-041X(1994)8:4<404:EOCOGR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Keywords:
CYCLOSPORINE A; GLOMERULAR FILTRATION RATE; NEPHROTIC SYNDROME; NEPHROTOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Hulton et al., "EFFECT OF CYCLOSPORINE-A ON GLOMERULAR-FILTRATION RATE IN CHILDREN WITH MINIMAL CHANGE NEPHROTIC SYNDROME", Pediatric nephrology, 8(4), 1994, pp. 404-407

Abstract

Cyclosporin A (CyA) is now commonly used in the management of children with steroid-dependent nephrotic syndrome. In order to assess nephrotoxicity related to CyA therapy, we measured glomerular filtration rate (GFR) on 123 occasions in 24 children with minimal change nephrotic syndrome receiving CyA. GFR was estimated from the plasma clearance of(51)chromium-EDTA every 3 months during CyA therapy of up to 27 months duration. There was a significant reduction in GFR after 3 months ofCyA therapy [118 +/- 33 (SD) to 93 +/- 24 ml/min per 1.73 m(2)] but no further fall thereafter, although the reduction in GFR was sustainedfor the duration of CyA therapy. This reduction in GFR appeared to bereversible upon cessation of CyA, but careful monitoring of renal function is necessary in such patients to prevent the development of longer term nephrotoxic sequelae.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 05:33:50