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Titolo:
LONG-TERM CYCLOSPORINE-A TREATMENT OF MINIMAL-CHANGE NEPHROTIC SYNDROME OF CHILDHOOD
Autore:
HULTON SA; NEUHAUS TJ; DILLON MJ; BARRATT TM;
Indirizzi:
CHILDRENS HOSP,DEPT NEPHROL BIRMINGHAM B16 8ET W MIDLANDS ENGLAND
Titolo Testata:
Pediatric nephrology
fascicolo: 4, volume: 8, anno: 1994,
pagine: 401 - 403
SICI:
0931-041X(1994)8:4<401:LCTOMN>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Keywords:
CYCLOSPORINE; MINIMAL-CHANGE NEPHROTIC SYNDROME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Hulton et al., "LONG-TERM CYCLOSPORINE-A TREATMENT OF MINIMAL-CHANGE NEPHROTIC SYNDROME OF CHILDHOOD", Pediatric nephrology, 8(4), 1994, pp. 401-403

Abstract

We evaluated the efficacy of long-term cyclosporin A (CyA) treatment in the maintenance of remission in 40 children with steroid-dependent minimal-change nephrotic syndrome (MCNS). CyA was given in an initial dose of 5 mg/kg per day, adjusted to maintain a trough whole blood level of 50-150 ng/ml. All the 40 children received CyA for 1 year. In 18patients, CyA was continued for a further period of at least a year without interruption; 9 patients had a second course of CyA therapy after an interval of at least 1 month. Of the 40 children 29 (72%) had one or more relapses during treatment with CyA, with 16 (40%) relapsing during the Ist year. During the second period of CyA, 10 (56%) of the 18 children treated continuously relapsed, whereas all the 9 children who had an interrupted course of therapy relapsed. CyA was discontinued at one time in 27 patients, all of whom subsequently relapsed, with a median time to relapse of 26 days. Long-term prednisolone in addition to CyA was required to maintain remission in 16 (40%) of the whole group. The results suggest that the long-term use of CyA is able to maintain remission of MCNS, although 40% of the patients also required low-dose alternate-day steroids; patients appeared to fare worse if the CyA course was interrupted; no patient experienced a long-term remission after CyA was stopped.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 05:10:22