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Titolo:
CCK ANTAGONISTS - PHARMACOLOGY AND THERAPEUTIC INTEREST
Autore:
WETTSTEIN JG; BUENO L; JUNIEN JL;
Indirizzi:
ITEM LABO,93 AVE FONTAINBLEAU F-94276 LE KREMLIN BICETR FRANCE INST RECH JOUVEINAL F-94265 FRESNES FRANCE INRA F-31931 TOULOUSE FRANCE
Titolo Testata:
Pharmacology & therapeutics
fascicolo: 3, volume: 62, anno: 1994,
pagine: 267 - 282
SICI:
0163-7258(1994)62:3<267:CA-PAT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MIDBRAIN DOPAMINE NEURONS; COLONIC MOTOR RESPONSE; CHOLECYSTOKININ-INDUCED ACTIVATION; PREVENTS MORPHINE-TOLERANCE; PASSIVE-AVOIDANCE RESPONSE; CEREBROSPINAL-FLUID CSF; B-RECEPTOR; RAT-BRAIN; NUCLEUS ACCUMBENS; PSYCHIATRIC-DISORDERS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
174
Recensione:
Indirizzi per estratti:
Citazione:
J.G. Wettstein et al., "CCK ANTAGONISTS - PHARMACOLOGY AND THERAPEUTIC INTEREST", Pharmacology & therapeutics, 62(3), 1994, pp. 267-282

Abstract

CCK was first identified and characterized in the digestive tract where it is known to be a factor involved in the control of gut motility. Later, CCK and CCK receptors were identified in regions of the central nervous system that are associated with the control of emotion, motivation and sensory processing. The recent discovery and development ofCCK-receptor antagonists having selective affinity for either CCKA orCCKB receptors has led to a better understanding of the functional role of CCK and its binding sites in the brain and periphery. Some of these compounds are being examined in man for their therapeutic usefulness in mental as well as in digestive disorders. This review will highlight the results from both basic and clinical investigations that haveexamined the effects of selective CCK receptor ligands. The focus will be on the central nervous system pharmacology of CCK antagonists andthe involvement of CCK in gastrointestinal and colonic motility.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 05:26:54