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Titolo:
ALCOHOL-DRINKING IN RATS TREATED WITH 5,7-DIHYDROXYTRYPTAMINE - EFFECT OF 8-OH-DPAT AND TROPISETRON (ICS-205-930)
Autore:
JANKOWSKA E; BIDZINSKI A; KOSTOWSKI W;
Indirizzi:
INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST PL-02957WARSAW POLAND INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST PL-02957WARSAW POLAND INST PSYCHIAT & NEUROL,DEPT BIOCHEM PL-02957 WARSAW POLAND
Titolo Testata:
Alcohol
fascicolo: 4, volume: 11, anno: 1994,
pagine: 283 - 288
SICI:
0741-8329(1994)11:4<283:AIRTW5>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-HT3 RECEPTOR ANTAGONIST; FREELY MOVING RATS; ETHANOL PREFERENCE; DOPAMINE RELEASE; NUCLEUS ACCUMBENS; PREFERRING P; BRAIN; NEURONS; STIMULATION; SEROTONIN;
Keywords:
ETHANOL; 5,7-DIHYDROXYTRYPTAMINE; ETHANOL PREFERENCE; 8-OH-DPAT; TROPISETRON; 5-HT1A RECEPTOR; 5-HT3 RECEPTOR; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
E. Jankowska et al., "ALCOHOL-DRINKING IN RATS TREATED WITH 5,7-DIHYDROXYTRYPTAMINE - EFFECT OF 8-OH-DPAT AND TROPISETRON (ICS-205-930)", Alcohol, 11(4), 1994, pp. 283-288

Abstract

5,7-Dihydroxytryptamine (5,7-DHT) was administered ICV to Wistar malerats. Lesioned rats displayed higher preference for ETOH than sham-lesioned animals. Among 5,7-DHT-pretreated rats 38% became high-preferring, while only 22% of sham-lesioned rats displayed this behavioural pattern (p < 0.05). Both 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT; the agonist of serotonin 5-HT1A receptors) and tropisetron (ICS 205-930, the antagonist of 5-HT3 receptors) reduced ETOH consumption in high-preferring, sham-lesioned rats. However, in 5,7-DHT rats the effect of 8-OH-DPAT was completely abolished, while tropisetron retained its antipreference activity. Therefore, it seems that 5-HT1A autoreceptors are critically involved in 8-OH-DPAT action, while 5-HT3 receptor sites responsible for tropisetron action are located beyond the 5-HT system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 11:04:47