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Titolo:
IMMUNOHISTOCHEMICAL LOCALIZATION OF KAPPA-OPIOID RECEPTORS IN THE HUMAN FRONTAL-CORTEX
Autore:
SCHMIDT P; SCHRODER H; MADERSPACH K; STAAK M;
Indirizzi:
UNIV COLOGNE,INST FORENS MED,MELATENGURTEL 60-62 D-50823 COLOGNE GERMANY UNIV COLOGNE,DEPT ANAT COLOGNE GERMANY HUNGARIAN ACAD SCI,BIOL RES CTR,INST BIOCHEM H-6701 SZEGED HUNGARY
Titolo Testata:
Brain research
fascicolo: 2, volume: 654, anno: 1994,
pagine: 223 - 233
SICI:
0006-8993(1994)654:2<223:ILOKRI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG BRAIN; OPIATE BINDING-SITES; RAT-BRAIN; AUTORADIOGRAPHIC LOCALIZATION; CEREBRAL-CORTEX; INVITRO AUTORADIOGRAPHY; SUPER-SENSITIVITY; H-3 BREMAZOCINE; DOWN-REGULATION; HUMAN FOREBRAIN;
Keywords:
HUMAN CEREBRAL CORTEX; KAPPA OPIOID RECEPTOR; IMMUNOHISTOCHEMISTRY; MONOCLONAL ANTIBODY KA8; ELECTRON MICROSCOPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
P. Schmidt et al., "IMMUNOHISTOCHEMICAL LOCALIZATION OF KAPPA-OPIOID RECEPTORS IN THE HUMAN FRONTAL-CORTEX", Brain research, 654(2), 1994, pp. 223-233

Abstract

The cellular and subcellular K opioid receptor distribution in human frontal cortex was studied using the monoclonal antibody (KA8). kappa opioid receptor-like immunoreactivity was mainly localized in pyramidal neurons of layers II/III and V. In addition, some round and ovoid neurons were found immunolabeled mainly in layer VI. At the ultrastructural level the immunoprecipitate was attached to the cell membrane but was not associated with synaptic specializations. Furthermore, labeling was present in the neuronal perikarya associated with free ribosomesand in the dendrites partly decorating microtubular structures. Previous autoradiographic findings remained restricted to the level of laminar distribution. By contrast, the monoclonal antibody KA8 provides a unique tool to study the cerebral kappa opioid receptor distribution on the cellular and subcellular level.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:18:28