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Titolo:
INTRAUTERINE TRANSPLANTATION OF ISOGENIC PANCREATIC-ISLETS IN EXPERIMENTAL DIABETIC RATS
Autore:
SAKONJU I; TAURA Y; NAKAICHI M; NAKAMA S; KAGABU S;
Indirizzi:
YAMAGUCHI UNIV,FAC AGR,DEPT VET SURG,1677-1 YOSHIDA YAMAGUCHI 753 JAPAN YAMAGUCHI UNIV,FAC AGR,DEPT VET ANAT YAMAGUCHI 753 JAPAN
Titolo Testata:
Journal of veterinary medical science
fascicolo: 4, volume: 56, anno: 1994,
pagine: 729 - 733
SICI:
0916-7250(1994)56:4<729:ITOIPI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALLOTRANSPLANTATION;
Keywords:
DIABETES; IMMUNOLOGICALLY PRIVILEGED SITE; PANCREATIC ISLETS TRANSPLANTATION; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
I. Sakonju et al., "INTRAUTERINE TRANSPLANTATION OF ISOGENIC PANCREATIC-ISLETS IN EXPERIMENTAL DIABETIC RATS", Journal of veterinary medical science, 56(4), 1994, pp. 729-733

Abstract

The effect of intrauterine transplantation (IU group) as a potential immunologically privileged site on the diabetic state of the recipientwas compared with that of conventional intraperitoneal transplantation (IP group) using Fischer 344 rats. Islets were isolated from the pancreata of normal rats and transplanted into the uterus and peritoneal cavity of the isogenic rats with experimental diabetes, which were treated with estradiol benzoate and progesterone. Although all the rats in both groups became normoglycemic within 4 days after transplantation, all of those in the IU group relapsed into a diabetic state up to the 20th day after transplantation. On the other hand, 6 of 8 rats in the IP group remained normoglycemic throughout the experimental period. Weight gain and diminution of urinary glucose excretion in the IU group were significantly lower than those in the IP group (P<0.01). The glycosylated hemoglobin level in the IU group did not differ significantly from that in the IP group, but the serum level of fructosamine in the IU group was significantly higher than that in the IP group (P<0.01). These results indicate that the response to fluctuations of blood glucose of islets in the uterine cavity is less than that of islets in the peritoneal cavity. Histologically, islets were observed to be aggregated in the uterine cavity, however the number of cells decreased markedly with time. Although this study demonstrated that blood glucose was normalized by transplantation of islets into the uterine cavity ofdiabetic rats, long-term survival of the islets in this location was not obtained.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:17:43