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Titolo:
IMAGING TRANSIENT, RANDOMLY OCCURRING NEUROPSYCHOLOGICAL EVENTS IN SINGLE SUBJECTS WITH POSITRON EMISSION TOMOGRAPHY - AN EVENT-RELATED COUNT RATE CORRELATIONAL ANALYSIS
Autore:
SILBERSWEIG DA; STERN E; SCHNORR L; FRITH CD; ASHBURNER J; CAHILL C; FRACKOWIAK RSJ; JONES T;
Indirizzi:
CORNELL UNIV,MED CTR,NEW YORK HOSP,DEPT PSYCHIAT,PAYNE WHITNEY CLIN,BOX 171,525 E 68 ST NEW YORK NY 10021 UNIV COLL LONDON,DEPT PSYCHOL LONDON ENGLAND HAMMERSMITH HOSP,MRC,CYCLOTRON UNIT LONDON W12 0HS ENGLAND CORNELL UNIV,MED CTR,NEW YORK HOSP,DEPT NEUROL & NEUROSCI NEW YORK NY10021 CORNELL UNIV,MED CTR,NEW YORK HOSP,DEPT RADIOL NEW YORK NY 10021
Titolo Testata:
Journal of cerebral blood flow and metabolism
fascicolo: 5, volume: 14, anno: 1994,
pagine: 771 - 782
SICI:
0271-678X(1994)14:5<771:ITRONE>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; RETRACTABLE SEPTA; PET IMAGES; INTRAVENOUS (H2O)-O-15; MOTOR CORTEX; HUMAN-BRAIN; MONKEY; DISCRIMINATION; RECONSTRUCTION; LOCALIZATION;
Keywords:
POSITRON EMISSION TOMOGRAPHY; REGIONAL CEREBRAL BLOOD FLOW; O-15-LABELED WATER; FUNCTIONAL BRAIN IMAGING; SLOW BOLUS TECHNIQUE; EVENT-RELATED COUNT RATE CORRELATIONAL ANALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
D.A. Silbersweig et al., "IMAGING TRANSIENT, RANDOMLY OCCURRING NEUROPSYCHOLOGICAL EVENTS IN SINGLE SUBJECTS WITH POSITRON EMISSION TOMOGRAPHY - AN EVENT-RELATED COUNT RATE CORRELATIONAL ANALYSIS", Journal of cerebral blood flow and metabolism, 14(5), 1994, pp. 771-782

Abstract

Many neuropsychiatric symptom states are idiosyncratic, involuntary, randomly occurring, subjective, and transient. The brain states associated with these clinically important mental states cannot be imaged directly with existing positron emission tomography (PET) techniques. A new PET method that brings such mental/brain states under experimentalcontrol for analysis in single subjects is described. It utilizes a slow bolus (H2O)-O-15 three-dimensional (3D) regional CBF imaging technique. The analysis focuses upon natural or experimentally induced variance in the temporal distribution of specific neuropsychological events over the course of a study session. For each scan, the amount of radioactivity entering the brain during these events is calculated to derive a score reflecting the contribution of the events to the image. A statistical analysis is then performed to identify those pixels in which the intensity covaries with the scan scores over the subject's scans. This permits the identification of the brain areas associated with the mental state of interest. The method is validated using an auditory sentence-monitoring task. The detection in single subjects of cerebral activations associated with recurrent events as brief as 2 s in duration is demonstrated. This method may be used as a means of imaging ephemeral neurologic or neuropsychiatric symptom states or as an alternative to a subtraction design for activation studies.

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Documento generato il 19/01/20 alle ore 21:00:23