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Titolo:
MITOCHONDRIAL CALCIUM-TRANSPORT - PHYSIOLOGICAL AND PATHOLOGICAL RELEVANCE
Autore:
GUNTER TE; GUNTER KK; SHEU SS; GAVIN CE;
Indirizzi:
UNIV ROCHESTER,DEPT BIOPHYS ROCHESTER NY 14642 UNIV ROCHESTER,DEPT PHARMACOL ROCHESTER NY 14642
Titolo Testata:
The American journal of physiology
fascicolo: 2, volume: 267, anno: 1994,
parte:, 1
pagine: 30000313 - 30000339
SICI:
0002-9513(1994)267:2<30000313:MC-PAP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-LIVER MITOCHONDRIA; PERMEABILITY TRANSITION PORE; INNER-MEMBRANE-PERMEABILITY; INTRAMITOCHONDRIAL CA-2+-SENSITIVE ENZYMES; 2-OXOGLUTARATE DEHYDROGENASE COMPLEX; LINKED ISOCITRATE DEHYDROGENASE; ELECTRICAL POTENTIAL GRADIENT; ISOLATED HEART-MITOCHONDRIA; EXPRESSING CREATINE-KINASE; CELLULAR-ENERGY METABOLISM;
Keywords:
OXIDATIVE PHOSPHORYLATION; CALCIUM HOMEOSTASIS; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; HYPOXIA; ISCHEMIA; INTRAMITOCHONDRIAL CALCIUM IN VIVO; CALCIUM AS A 2ND MESSENGER; METABOLIC CALCIUM ACTIVATION SITES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
429
Recensione:
Indirizzi per estratti:
Citazione:
T.E. Gunter et al., "MITOCHONDRIAL CALCIUM-TRANSPORT - PHYSIOLOGICAL AND PATHOLOGICAL RELEVANCE", The American journal of physiology, 267(2), 1994, pp. 30000313-30000339

Abstract

Since the initiation of work on mitochondrial Ca2+ transport in the early 1960s, the relationship between experimental observations and physiological function has often seemed enigmatic. Why, for example, should an organelle dedicated to the crucial task of producing similar to 95% of the cell's ATP sequester Ca2+, sometimes in preference to phosphorylating ADP? Why should there be two separate efflux mechanisms, the Na+ independent and the Na+ dependent, both thought until recently to be driven exclusively either directly or indirectly by the energy ofthe pH gradient? Does intramitochondrial free Ca2+ concentration control metabolism? Is there evidence for any separate function of the mitochondrial Ca2+ transport mechanisms under pathological conditions? What is the relation ship between mitochondrial Ca2+ transport, the mitochondrial membrane permeability transition, and irreversible cell damage under pathological conditions? First, we review what is known aboutcontrol of metabolism, evidence for a role for intramitochondrial Ca2 in control of metabolism, the cellular conditions under which mitochondria are exposed to Ca2+, characteristics of the mitochondrial Ca2+ transport mechanisms including the permeability transition, and evidence for and against mitochondrial Ca2+ uptake in vivo. Then the questions listed above and others are addressed from the perspective of the characteristics of the mechanisms of mitochondrial Ca2+ transport.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 11:51:24