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Titolo:
EXTENDED DOSAGE INTERVALS FOR AMINOGLYCOSIDES
Autore:
RODMAN DP; MAXWELL AJ; MCKNIGHT JT;
Indirizzi:
CAPSTONE MED CTR,700 UNIV BLVD E TUSCALOOSA AL 35401 AUBURN UNIV,SCH PHARM,DEPT CLIN PHARM PRACTICE AUBURN AL 36849 UNIV ALABAMA,SCH MED,DEPT FAMILY MED TUSCALOOSA AL 35401
Titolo Testata:
American journal of hospital pharmacy
fascicolo: 16, volume: 51, anno: 1994,
pagine: 2016 - 2021
SICI:
0002-9289(1994)51:16<2016:EDIFA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENTAMICIN-NEPHROTOXICITY; SERIOUS INFECTIONS; NETILMICIN; THERAPY; TOBRAMYCIN; AMIKACIN; EFFICACY; TOXICITY; COMBINATION; OTOTOXICITY;
Keywords:
AMINOGLYCOSIDES; CLINICAL STUDIES; DOSAGE SCHEDULES; TOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
D.P. Rodman et al., "EXTENDED DOSAGE INTERVALS FOR AMINOGLYCOSIDES", American journal of hospital pharmacy, 51(16), 1994, pp. 2016-2021

Abstract

The rationale for and effectiveness of extended dosage intervals for aminoglycosides are discussed. Aminoglycosides can be given once dailydespite an elimination half-life of two to three hours because of thepostantibiotic effect (PAE) of these agents. Aminoglycosides have a prolonged PAE against a variety of common gram-negative and gram-positive organisms. Higher serum aminoglycoside concentrations are associated with longer PAEs and increased bactericidal activity. Once-daily administration may re-duce the potential for adaptive postexposure resistance by allowing less contact time between organism and drug. A major concern with aminoglycosides is the risk of nephrotoxicity and ototoxicity. The uptake of specific aminoglycosides by renal cortical cells is saturable; a longer dosage interval may decrease the risk of nephrotoxicity because higher transient serum aminoglycoside levels appear tobe less nephrotoxic than lower but more persistent serum concentrations. Once-daily administration may reduce the risk of ototoxicity through a similar mechanism. An increasing number of clinical trials suggest that once-daily administration of aminoglycosides and regimens involving shorter dosage intervals are equally effective in patients with normal renal function and gramnegative infections and that once-daily administration may reduce the frequency of toxicity or delay it. Patients with renal dysfunction or neutropenia may also benefit from once-daily administration. Most trials have been small, and in some of them other antimicrobials were given concurrently. Although more study is needed, the evidence to date suggests that once-daily administration of aminoglycosides is as effective as traditional regimens entailing shorter dosage intervals and may reduce the potential for toxicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 17:08:53