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Titolo:
INDUCTION OF C-FOS AND C-MYC ONCOGENE EXPRESSION IN THE PYLORIC MUCOSA OF RAT STOMACH BY N-METHYL-N'-NITRO-N-NITROSOGUANIDINE AND TAUROCHOLATE
Autore:
FURIHATA C; YAMAKOSHI A; HATTA A; TATEMATSU M; IWATA H; HAYASHI K; UMEZAWA K; MATSUSHIMA T;
Indirizzi:
UNIV TOKYO,INST MED SCI,DEPT MOLEC ONCOL,MINATO KU,SHIROKANEDAI 4-6-1TOKYO 108 JAPAN AICHI CANC CTR,RES INST,DEPT PATHOL 1,CHIGUSA KU NAGOYA AICHI 464 JAPAN KYUSHU UNIV,INST GENET INFORMAT,DIV GENOME ANAL,HIGASHI KU FUKUOKA 812 JAPAN KEIO UNIV,FAC SCI & TECHNOL,DEPT APPL CHEM,KOHOKU KU YOKOHAMA KANAGAWA 223 JAPAN
Titolo Testata:
Cancer letters
fascicolo: 1-2, volume: 83, anno: 1994,
pagine: 215 - 220
SICI:
0304-3835(1994)83:1-2<215:IOCACO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORNITHINE DECARBOXYLASE; GLANDULAR STOMACH; DNA-SYNTHESIS; GENE; CARCINOGENS; PROTEIN; CELLS;
Keywords:
C-FOS; C-MYC; N-METHYL-N'-NITRO-N-NITROSOGUANIDINE; TAUROCHOLATE; RAT STOMACH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
C. Furihata et al., "INDUCTION OF C-FOS AND C-MYC ONCOGENE EXPRESSION IN THE PYLORIC MUCOSA OF RAT STOMACH BY N-METHYL-N'-NITRO-N-NITROSOGUANIDINE AND TAUROCHOLATE", Cancer letters, 83(1-2), 1994, pp. 215-220

Abstract

The induction of c-fos and c-myc expression in the pyloric mucosa of 8-week-old F344 male rats after oral administration of the glandular stomach carcinogen, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), or thetumor-promoter, taurocholate, was examined by Northern blotting. MNNGat doses of 5-50 mg/kg body weight dose-dependently induced transientincrease of up to 30-fold c-fos expression with a maximum after 30 min, and of 8-fold c-myc expression with a maximum after 3 h. It also induced up to 3-fold increase in S-phase cells in the proliferation zoneof the pyloric mucosa after 16 h. Similar effects were observed with sodium taurocholate at doses of 200-800 mg/kg body weight. These results suggest that c-fos and c-myc oncogenes play a role in stomach carcinogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 07:27:26