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Titolo:
TREATMENT OF ALPRAZOLAM WITHDRAWAL WITH CHLORDIAZEPOXIDE SUBSTITUTIONAND TAPER
Autore:
CLOSSER MH; BROWER KJ;
Indirizzi:
UNIV MICHIGAN,CTR ALCOHOL RES,400 E EISENHOWER,SUITE A ANN ARBOR MI 48104 CHELSEA ARBOR TREATMENT CTR CHELSEA MI 00000 UNIV MICHIGAN,DEPT PSYCHIAT ANN ARBOR MI 48109 DEPT VET AFFAIRS MED CTR,SUBSTANCE ABUSE CLIN ANN ARBOR MI 00000
Titolo Testata:
Journal of substance abuse treatment
fascicolo: 4, volume: 11, anno: 1994,
pagine: 319 - 323
SICI:
0740-5472(1994)11:4<319:TOAWWC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAINTENANCE DRUG-TREATMENT; PANIC DISORDER; DISCONTINUATION; DIAZEPAM; BENZODIAZEPINES; DETOXIFICATION; ABUSE; TERM;
Keywords:
ALPRAZOLAM; CHLORDIAZEPOXIDE; BENZODIAZEPINES; SUBSTANCE WITHDRAWAL; SUBSTANCE DEPENDENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social Sciences Citation Index
Social Sciences Citation Index
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
M.H. Closser e K.J. Brower, "TREATMENT OF ALPRAZOLAM WITHDRAWAL WITH CHLORDIAZEPOXIDE SUBSTITUTIONAND TAPER", Journal of substance abuse treatment, 11(4), 1994, pp. 319-323

Abstract

We describe the first case series (n = 6) of using chlordiazepoxide to accomplish a rapid, well-tolerated withdrawal from alprazolam. Afterabruptly discontinuing alprazolam, we substituted a 50-mg dose of chlordiazepoxide for each 1 mg of alprazolam (except for one elderly patient where we substituted 25 mg) and gave additional chlordiazepoxide doses (25-50 mg every 4-6 hours) as needed for the first 1-2 days of hospitalization. With this approach, the mean ''substitution ratio'' of chlordiazepoxide to alprazolam was 86 to 1. We then tapered chlordiazepoxide by an average of 10% each day over a 7- to 14-day period according to the symptoms manifested and tolerated by individual patients. No seizures or other serious side effects occurred. Incomplete cross-dependence, as described elsewhere in the literature, was not observed. The rapidity and familiarity of the method are advantages for inpatient units, but careful titration of dosage, diagnostic clarity, and extended follow-ups are necessary when applying this approach.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:25:25