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Titolo:
NOREPINEPHRINE MODULATES EXCITATORY AMINO ACID-INDUCED RESPONSES IN DEVELOPING HUMAN AND ADULT-RAT CEREBRAL-CORTEX
Autore:
RADISAVLJEVIC Z; CEPEDA C; PEACOCK W; BUCHWALD NA; LEVINE MS;
Indirizzi:
UNIV CALIF LOS ANGELES,MENTAL RETARDAT RES CTR LOS ANGELES CA 90024 UNIV CALIF LOS ANGELES,MENTAL RETARDAT RES CTR LOS ANGELES CA 90024 UNIV CALIF LOS ANGELES,DIV NEUROSURG LOS ANGELES CA 90024
Titolo Testata:
International journal of developmental neuroscience
fascicolo: 4, volume: 12, anno: 1994,
pagine: 353 - 361
SICI:
0736-5748(1994)12:4<353:NMEAAR>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICAL NEURONAL RESPONSES; DOPAMINE-BETA-HYDROXYLASE; PUTATIVE NEUROTRANSMITTERS; NORADRENERGIC MODULATION; NEOCORTICAL NEURONS; RECEPTOR SUBTYPES; NMDA RECEPTORS; INVITRO; NORADRENALINE; SLICES;
Keywords:
AMPA RECEPTORS; BETA-ADRENOCEPTORS; GLUTAMATE; NMDA RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
Z. Radisavljevic et al., "NOREPINEPHRINE MODULATES EXCITATORY AMINO ACID-INDUCED RESPONSES IN DEVELOPING HUMAN AND ADULT-RAT CEREBRAL-CORTEX", International journal of developmental neuroscience, 12(4), 1994, pp. 353-361

Abstract

These experiments were designed to assess the ability of norepinephrine and its beta-receptor agonist, isoproterenol, to modulate responsesinduced by activation of excitatory amino acid receptors in brain slices obtained from developing human cortex or adult rat cortex. Human cortical slices were obtained from children undergoing surgery for intractable epilepsy (9 months to 10 yr of age). For comparison, slices were also obtained from rats (2-3 months of age). Iontophoretic application of glutamate, N-methyl-D-aspartate or lpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) produced excitatory responses consisting of membrane depolarizations accompanied by action potentials. Iontophoretic or bath application of norepinephrine or isoproterenol enhanced responses evoked by glutamate or N-methyl-D-aspartate. Depolarizations occurred with shorter latencies and their amplitudes increased. Action potential frequency was also increased and responses were of longer duration. In contrast, norepinephrine or isoproterenol had no effect on responses induced by AMPA. The enhancement of responses induced by N-methyl-D-aspartate or glutamate was antagonized by the beta-adrenergic receptor antagonist propranolol. Similar findings were obtained from neurons in humans or rats. These results suggest that norepinephrine, possibly via beta-receptors, potentiates responses mediated by glutamate and N-methyl-D-aspartate receptors without affecting those mediated by AMPA receptors. These effects were observed at all ages studied, indicating that the ability of norepinephrine to modulate excitatory neuronal transmission is well developed in human cortex by 9 months of age.

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Documento generato il 21/09/20 alle ore 11:14:49