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Titolo:
FOLATE, VITAMIN-B-12, AND HOMOCYSTEINE IN MAJOR DEPRESSIVE DISORDER
Autore:
FAVA M; BORUS JS; ALPERT JE; NIERENBERG AA; ROSENBAUM JF; BOTTIGLIERI T;
Indirizzi:
MASSACHUSETTS GEN HOSP,CLIN PSYCHOPHARMACOL UNIT,DEPRESS CLIN & RES PROGRAM,WACC 815 BOSTON MA 02114 BAYLOR RES INST,METAB DIS CTR DALLAS TX 00000
Titolo Testata:
The American journal of psychiatry
fascicolo: 3, volume: 154, anno: 1997,
pagine: 426 - 428
SICI:
0002-953X(1997)154:3<426:FVAHIM>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURAL-TUBE DEFECTS; PLASMA; SERUM; METHYLATION; DEFICIENCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
M. Fava et al., "FOLATE, VITAMIN-B-12, AND HOMOCYSTEINE IN MAJOR DEPRESSIVE DISORDER", The American journal of psychiatry, 154(3), 1997, pp. 426-428

Abstract

Objective: The authors examined the relationships between levels of three metabolites (folate, vitamin B-12, and homocysteine) and both depressive subtype and response to fluoxetine treatment in depressed patients. Method: Fluoxetine, 20 mg/day for 8 weeks, was given to 213 outpatients with major depressive disorder. At baseline, depressive subtypes were assessed and a blood sample was collected from each patient. Serum metabolite levels were assayed. Response to treatment was determined by percentage change in score on the 17-item Hamilton Depression Rating Scale. Results: Subjects with low folate levels were move likelyto have melancholic depression and were significantly less likely to respond to fluoxetine. Homocysteine and B-12 levels were not associated with depressive subtype or treatment response. Conclusions: Overall,the results are consistent with findings linking low folate levels topoorer response to antidepressant treatment. Folate levels might be considered in the evaluation of depressed patients who do not respond to antidepressant treatment.

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Documento generato il 20/09/20 alle ore 19:32:36