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Titolo:
THE HUMAN UBIQUITIN-CONJUGATING ENZYME UBCH1 IS INVOLVED IN THE REPAIR OF UV-DAMAGED, ALKYLATED AND CROSS-LINKED DNA
Autore:
KAISER P; MANSOUR HA; GREETEN T; AUER B; SCHWEIGER M; SCHNEIDER R;
Indirizzi:
INNSBRUCK UNIV,INST BIOCHEM,PETER MAYR STR 1A A-6020 INNSBRUCK AUSTRIA INNSBRUCK UNIV,INST BIOCHEM A-6020 INNSBRUCK AUSTRIA
Titolo Testata:
FEBS letters
fascicolo: 1, volume: 350, anno: 1994,
pagine: 1 - 4
SICI:
0014-5793(1994)350:1<1:THUEUI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
YEAST SACCHAROMYCES-CEREVISIAE; N-END RULE; GENE RAD6; ESCHERICHIA-COLI; CARRIER PROTEIN; DOMAIN; CELLS; IDENTIFICATION; TRANSFORMATION; EXPRESSION;
Keywords:
DNA REPAIR; UBIQUITIN CONJUGATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
P. Kaiser et al., "THE HUMAN UBIQUITIN-CONJUGATING ENZYME UBCH1 IS INVOLVED IN THE REPAIR OF UV-DAMAGED, ALKYLATED AND CROSS-LINKED DNA", FEBS letters, 350(1), 1994, pp. 1-4

Abstract

The human ubiquitin-conjugating enzyme UbcH1 shows 69% identity to the Saccharomyces cerevisiae RAD6/UBC2 which plays a key role in DNA repair. To examine the function of UbcH1 (formerly named E2, M(r) 17 000), [(1990) EMBO J. 9, 1431-1435]) we tested its ability to functionallysubstitute for yeast RAD6/UBC2 in the recovery of cells from various DNA damage. Complementation by expression of the human UbcH1 cDNA revealed that the UbcH1 carries out the function of S. cerevisiae RAD6/UBC2 in the repair of W-damaged, alkylated and cross-linked DNA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/06/20 alle ore 15:45:26