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Titolo: SYNTHESIS OF SOME DIBENZODIAZEPIONE DERIVATIVES AS POTENT AND M2-SELECTIVE ANTIMUSCARINIC COMPOUNDS
Autore: COHEN VI; JIN BY; GITLER MS; DELACRUZ RA; RZESZOTARSKI WJ; ZEEBERG BR; BAUMGOLD J; REBA RC;
- Indirizzi:
- GEORGE WASHINGTON UNIV,MED CTR,RADIOPHARMACEUT CHEM SECT WASHINGTON DC 20037 UNIV CHICAGO HOSP & CLIN,DEPT RADIOL,NUCL MED SECT CHICAGO IL 60637
- Titolo Testata:
- Journal of heterocyclic chemistry
fascicolo: 4,
volume: 31,
anno: 1994,
pagine: 787 - 791
- SICI:
- 0022-152X(1994)31:4<787:SOSDDA>2.0.ZU;2-W
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- ACETYLCHOLINE-RECEPTOR GENES; BINDING; EXPRESSION; SUBTYPES; CYCLASE; LIGAND;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Science Citation Index Expanded
- Citazioni:
- 13
- Recensione:
- Indirizzi per estratti:
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- Citazione:
- V.I. Cohen et al., "SYNTHESIS OF SOME DIBENZODIAZEPIONE DERIVATIVES AS POTENT AND M2-SELECTIVE ANTIMUSCARINIC COMPOUNDS", Journal of heterocyclic chemistry, 31(4), 1994, pp. 787-791
Abstract
Two series of -[[4-[4-(dialkylamino)butyl]-1-cyclohexyl]acetyl], and 10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-11-ones were synthesized aspotential m2-selective ligands 1,2. Their affinity and selectivity for the muscarinic cholinergic receptor m-AChR subtypes were determined. Replacing a nitrogen with CH in the piperidine ring of 0,11-dihydro-5H-dibenzo-[b,e][1,4]diazepin-11-ones 3 significantly altered the affinity and selectivity to the muscarinic receptor subtypes.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 07:28:55