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Titolo:
EFFECT OF CHENODEOXYCHOLIC ACID AND URSODEOXYCHOLIC ACID ADMINISTRATION ON ACYL-COA - CHOLESTEROL ACYLTRANSFERASE ACTIVITY IN HUMAN LIVER
Autore:
ABATE N; CARUBBI F; BOZZOLI M; BERTOLOTTI M; FARAH I; ROSI A; CARULLI N;
Indirizzi:
UNIV MODENA,POLICLIN,IST PATOL MED,VIA POZZO 71 I-41100 MODENA ITALY UNIV MODENA,POLICLIN,IST PATOL MED,VIA POZZO 71 I-41100 MODENA ITALY OSPED CASTELFRANCO EMILIA,DIV CHIRURG GEN MODENA ITALY
Titolo Testata:
The Italian Journal of Gastroenterology
fascicolo: 6, volume: 26, anno: 1994,
pagine: 287 - 293
SICI:
0392-0623(1994)26:6<287:EOCAAU>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
COENZYME-A; HEPATIC CHOLESTEROL; GALLSTONE DISEASE; BILE-ACIDS; RAT-LIVER; LIPID-COMPOSITION; POOL COMPOSITION; METABOLISM; REDUCTASE; CHOLESTYRAMINE;
Keywords:
ACYL-COA; BILE ACIDS; CHOLESTEROL, CHOLESTEROL ACYLTRANSFERASE; LIVER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
N. Abate et al., "EFFECT OF CHENODEOXYCHOLIC ACID AND URSODEOXYCHOLIC ACID ADMINISTRATION ON ACYL-COA - CHOLESTEROL ACYLTRANSFERASE ACTIVITY IN HUMAN LIVER", The Italian Journal of Gastroenterology, 26(6), 1994, pp. 287-293

Abstract

In order to investigate the relationship between bile acid pool composition and hepatic cholesterol metabolism in humans, we studied the effect of chronic feeding of chenodeoxycholic (CDCA) or ursodeoxycholic acid (UDCA) on the hepatic activity of acyl-CoA: cholesterol acyltransferase (ACAT) evaluated ''in vitro''. Twenty-eight gallstone patients were admitted to the study: 15 were untreated subjects, 8 were treatedwith UDCA (10 mg/kg/day for 15-20 days) and 5 were treated with CDCA (15 mg/kg/day for 15-20 days). A liver specimen and a bile sample wereobtained during laparotomy for elective cholecystectomy. Untreated subjects had bile supersaturated with cholesterol (mean saturation index: 1.35 +/- 0.31) whereas subjects treated with either UDCA or CDCA hadbile unsaturated with cholesterol (mean saturation index: 0.66 +/- 0.1 and 0.75 +/- 0.06 respectively). In all treated subjects the bile acid administered became predominant in bile. ACAT activity was 14% lower in subjects treated with UDCA and 16% lower in those treated with CDCA compared to controls; the differences did not achieve statistical significance. Microsomal cholesterol content did not differ between thegroups (75.4 +/- 7.2 nmol/mg protein in control group; 86.5 +/- 7.0 nmol/mg protein in CDCA treated group; 83.4 +/- 7.0 nmol/mg protein in UDCA treated group). Our data show that the cholesterol esterifying activity of human liver is not affected by changes in bile acid pool composition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 03:18:54