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Titolo:
CLOPIDOGREL IS MORE EFFECTIVE THAN ASPIRIN AS ADJUVANT TREATMENT TO PREVENT REOCCLUSION AFTER THROMBOLYSIS
Autore:
YAO SK; OBER JC; FERGUSON JJ; MAFFRAND JP; ANDERSON HV; BUJA LM; WILLERSON JT;
Indirizzi:
UNIV TEXAS,SCH MED,DEPT INTERNAL MED,POB 20708 HOUSTON TX 77225 UNIV TEXAS,SCH MED,DEPT INTERNAL MED HOUSTON TX 77225 UNIV TEXAS,SCH MED,DEPT PATHOL & LAB MED HOUSTON TX 77225 ST LUKES EPISCOPAL HOSP,TEXAS HEART INST,CARDIOVASC RES LAB HOUSTON TX 00000 SANOFI RECH F-31036 TOULOUSE FRANCE
Titolo Testata:
The American journal of physiology
fascicolo: 2, volume: 267, anno: 1994,
parte:, 2
pagine: 80000488 - 80000493
SICI:
0002-9513(1994)267:2<80000488:CIMETA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; CORONARY-ARTERY REPERFUSION; PLATELET ADENYLATE-CYCLASE; CYCLIC FLOW VARIATIONS; LOW-DOSE ASPIRIN; PLASMINOGEN-ACTIVATOR; THIENOPYRIDINE CLOPIDOGREL; DELAYS REOCCLUSION; CANINE PREPARATION; ADP PLAYS;
Keywords:
ADENOSINE DIPHOSPHATE; TISSUE-TYPE PLASMINOGEN ACTIVATOR; HEPARIN; PLATELET AGGREGATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
S.K. Yao et al., "CLOPIDOGREL IS MORE EFFECTIVE THAN ASPIRIN AS ADJUVANT TREATMENT TO PREVENT REOCCLUSION AFTER THROMBOLYSIS", The American journal of physiology, 267(2), 1994, pp. 80000488-80000493

Abstract

Clopidogrel is a thienopyridine derivative and a potent inhibitor of ADP-induced platelet aggregation. We compared clopidogrel with aspirinas an adjunctive treatment to tissue-type plasminogen activator (t-PA) for thrombolysis and reocclusion. Thrombosis was induced in coronaryarteries of 32 dogs by injuring the endothelium with an electric charge. Coronary blood flow velocity was monitored by a pulsed Doppler flow probe placed around the artery. After the artery had been occluded by a thrombus for 3 continuous hours, each animal was given one of the following intravenous treatments: 1) t-PA (80 mu g/kg + 8 mu g.kg(-1).h(-1)) and heparin (200 U/kg) (group 1, n = 7); 2) t-PA, heparin, and aspirin (5 mg/kg) (group 2, n = 8); 3) t-PA, heparin, and clopidogrel (5 mg/kg) (group 3, n = 9); and 4) t-PA, heparin, and clopidogrel (10 mg/kg + 2.5 mg.kg(-1).h(-1)) (group 4, n = 8). After treatment, thrombolysis developed in 45 +/- 12 min in group 1, 39 +/- 10 min in group 2, 39 +/- 10 min in group 3, and 27 +/- 10 min in group 4 (compared with group 1, P > 0.05). After thrombolysis, reocclusion occurred in 5 of5 dogs in group 1 and 7 of 7 in group 2, but only 2 of 7 in group 3 and none of 7 in group 4 (compared with groups 1 and 2, P < 0.001). Thetimes from thrombolysis to reocclusion were 72 +/- 11 min in group 1,74 +/- 13 min in group 2, and 153 +/- 19 min in group 3 (compared with groups 1 and 2, P < 0.01). Thus, as an adjunctive treatment to t-PA and heparin, clopidogrel delays or prevents coronary artery reocclusion more effectively than aspirin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:42:49