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Titolo:
CEREBROSPINAL-FLUID IN THE DIAGNOSIS OF MULTIPLE-SCLEROSIS - A CONSENSUS REPORT
Autore:
ANDERSSON M; ALVAREZCERMENO J; BERNARDI G; COGATO I; FREDMAN P; FREDERIKSEN J; FREDRIKSON S; GALLO P; GRIMALDI LM; GRONNING M; KEIR G; LAMERS K; LINK H; MAGALHAES A; MASSARO AR; OHMAN S; REIBER H; RONNBACK L; SCHLUEP M; SCHULLER E; SINDIC CJM; THOMPSON EJ; TROJANO M; WURSTER U;
Indirizzi:
INST NEUROL,QUEEN SQ LONDON WC1N 3BG ENGLAND SAHLGRENS UNIV HOSP GOTHENBURG SWEDEN HOSP RAMON Y CAJAL E-28034 MADRID SPAIN INST NATL NEUROL C BESTA MILAN ITALY CENT HOSP MOLNDAL MOLNDAL SWEDEN OSPED CIVILE PARMA ITALY GENTOFTE UNIV HOSP DK-2900 COPENHAGEN DENMARK KAROLINSKA INST HUDDINGE SWEDEN INST NEUROL PADUA ITALY HOSP SAN RAFFAELE I-20132 MILAN ITALY INST NEUROL & NEUROSURG BERGEN NORWAY UNIV NIJMEGEN ST RADBOUD HOSP 6500 HB NIJMEGEN NETHERLANDS INST NEUROL LISBON PORTUGAL OSPED SACRO CUORE ROME ITALY LINKOPING UNIV HOSP S-58185 LINKOPING SWEDEN UNIV GOTTINGEN,NEUROL CLIN W-3400 GOTTINGEN GERMANY CHU VAUDOIS CH-1011 LAUSANNE SWITZERLAND HOP LA PITIE SALPETRIERE PARIS FRANCE UNIV CATHOLIQUE LOUVAIN B-1200 BRUSSELS BELGIUM UNIV BARI,NEUROL CLIN BARI ITALY HANNOVER MED SCH W-3000 HANNOVER GERMANY
Titolo Testata:
Journal of Neurology, Neurosurgery and Psychiatry
fascicolo: 8, volume: 57, anno: 1994,
pagine: 897 - 902
SICI:
0022-3050(1994)57:8<897:CITDOM>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL NERVOUS-SYSTEM; FREE LIGHT-CHAINS; INTRATHECAL IMMUNOGLOBULIN-SYNTHESIS; NEUROLOGICAL DISEASES; REFERENCE VALUES; OLIGOCLONAL IGG; LOCAL SYNTHESIS; PROTEIN; CSF; DISORDERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
M. Andersson et al., "CEREBROSPINAL-FLUID IN THE DIAGNOSIS OF MULTIPLE-SCLEROSIS - A CONSENSUS REPORT", Journal of Neurology, Neurosurgery and Psychiatry, 57(8), 1994, pp. 897-902

Abstract

The Committee of the European-Concerted Action for Multiple Sclerosis(Charcot Foundation) organised five workshops to discuss CSF analytical standards in the diagnosis of multiple sclerosis. This consensus report from 12 European countries summarises the results of those workshops. It is hoped that neurologists will confer with their colleagues in clinical chemistry to arrange the best possible local practice. The most sensitive method for the detection of oligoclonal immunoglobulin bands is isoelectric focusing. The same amounts of IgG in parallel CSFand serum samples are used and oligoclonal bands are revealed with IgG specific antibody staining. Ah laboratories performing isoelectric focusing should check their technique at least annually using ''blind''standards for the five different CSF and serum patterns. Quantitativemeasurements of IgG production in the CNS are less sensitive than isoelectric focusing. The preferred method for detection of blood-CSF barrier dysfunction is the albumin quotient. The CSF albumin or total protein concentrations are less satisfactory. These results must be interpreted with reference to the age of the patient and the local method of determination. Cells should be counted. The normal value is no more than 4 cells/mu l. Among evolving optional tests, measurement of the combined local synthesis of antibodies against measles, rubella, and/orvaricella tester could represent a significant advance if it offers higher specificity (not sensitivity) for identifying chronic rather than acute inflammation. Other tests that may have useful correlations with clinical indices include those for oligoclonal free light chains, IgM, IgA, or myelin basic protein concentrations.

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Documento generato il 02/12/20 alle ore 18:12:00