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Titolo:
EVOLUTIONARY PATTERN OF HUMAN RESPIRATORY SYNCYTIAL VIRUS (SUBGROUP-A) - COCIRCULATING LINEAGES AND CORRELATION OF GENETIC AND ANTIGENIC CHANGES IN THE G-GLYCOPROTEIN
Autore:
GARCIA O; MARTIN M; DOPAZO J; ARBIZA J; FRABASILE S; RUSSI J; HORTAL M; PEREZBRENA P; MARTINEZ I; GARCIABARRENO B; MELERO JA;
Indirizzi:
INST SALUD CARLOS 3,CTR NACL MICROBIOL,MAJADAHONDA E-28220 MADRID SPAIN INST SALUD CARLOS 3,CTR NACL MICROBIOL E-28220 MADRID SPAIN UNIV AUTONOMA MADRID,CSIC,CTR NACL BIOTECNOL E-28049 MADRID SPAIN LAB SALUD PUBL MONTEVIDEO 2720 URUGUAY
Titolo Testata:
Journal of virology
fascicolo: 9, volume: 68, anno: 1994,
pagine: 5448 - 5459
SICI:
0022-538X(1994)68:9<5448:EPOHRS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MISMATCH CLEAVAGE METHOD; INFLUENZA-B-VIRUS; MONOCLONAL-ANTIBODIES; SEQUENCE VARIABILITY; NUCLEOTIDE-SEQUENCE; ATTACHMENT PROTEIN; O-GLYCOSYLATION; POINT MUTATIONS; HEMAGGLUTININ; IDENTIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
O. Garcia et al., "EVOLUTIONARY PATTERN OF HUMAN RESPIRATORY SYNCYTIAL VIRUS (SUBGROUP-A) - COCIRCULATING LINEAGES AND CORRELATION OF GENETIC AND ANTIGENIC CHANGES IN THE G-GLYCOPROTEIN", Journal of virology, 68(9), 1994, pp. 5448-5459

Abstract

The genetic and antigenic variability of the G glycoproteins from 76 human respiratory syncytial (RS) viruses (subgroup A) isolated during six consecutive epidemics in either Montevideo, Uruguay, or Madrid, Spain, have been analyzed. Genetic diversity was evaluated for all viruses by the RNase A mismatch cleavage method and for selected strains bydideoxy sequencing. The sequences reported here were added to those published for six isolates from Birmingham, United Kingdom, and for tworeference strains (A2 and Long), to derive a phylogenetic tree of subgroup A viruses that contained two main branches and several subbranches. During the same epidemic, viruses from different branches were isolated. In addition, closely related viruses were isolated in distant places and in different years. These results illustrate the capacity ofthe virus to spread worldwide, influencing its mode of evolution. Theantigenic analysis of all isolates was carried out with a panel of anti-G monoclonal antibodies that recognized strain-specific (or variable) epitopes. A close correlation between genetic relatedness and antigenic relatedness in the G protein was observed. These results, together with an accumulation of amino acid changes in a major antigenic areaof the G glycoprotein, suggest that immune selection may be a factor influencing the generation of RS virus diversity. The pattern of RS virus evolution is thus similar to that described for influenza type B viruses, except that the level of genetic divergence among the G glycoproteins of RS virus isolates is the highest reported for an RNA virus gene product.

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Documento generato il 09/04/20 alle ore 19:47:16