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Titolo:
SERA FROM SOME PATIENTS WITH ANTIBODY-ASSOCIATED PARANEOPLASTIC ENCEPHALOMYELITIS SENSORY NEURONOPATHY RECOGNIZE THE RO-52K ANTIGEN
Autore:
MANLEY G; WONG E; DALMAU J; ELKON K; POSNER J; FURNEAUX H;
Indirizzi:
MEM SLOAN KETTERING CANC CTR,MOLEC NEUROONCOL LAB,1275 YORK AVE NEW YORK NY 10021 MEM SLOAN KETTERING CANC CTR,MOLEC NEUROONCOL LAB NEW YORK NY 10021 MEM SLOAN KETTERING CANC CTR,DEPT NEUROL NEW YORK NY 10021 HOSP SPECIAL SURG,DIV RHEUMAT DIS NEW YORK NY 10021
Titolo Testata:
Journal of neuro-oncology
fascicolo: 2, volume: 19, anno: 1994,
pagine: 105 - 112
SICI:
0167-594X(1994)19:2<105:SFSPWA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; CELL LUNG-CANCER; SENSORY NEURONOPATHY; SJOGRENS-SYNDROME; SS-A; AUTOANTIBODIES; PROTEINS; ELAV;
Keywords:
PARANEOPLASTIC; RO-52 K;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
G. Manley et al., "SERA FROM SOME PATIENTS WITH ANTIBODY-ASSOCIATED PARANEOPLASTIC ENCEPHALOMYELITIS SENSORY NEURONOPATHY RECOGNIZE THE RO-52K ANTIGEN", Journal of neuro-oncology, 19(2), 1994, pp. 105-112

Abstract

Screening a small cell lung cancer cDNA library with serum from a patient with antibody-associated paraneoplastic sensory neuronopathy (Anti-Hu syndrome) resulted in the isolation of a cDNA clone encoding the Ro-52 kD antigen. The Ro-52 kD antigen is one of the major antigens recognized by the sera of patients with Sjogren's syndrome and systemic lupus erythematosus. Further investigation revealed that the sera of only a small percentage (4%) of patients with the Hu syndrome reacted with Ro-52 kD antigen. The cross-reactivity may result from a domain ofhigh homology between Ro-52 kD and the HuD antigen. These results emphasize the necessity of using recombinant antigens whenever possible when assaying for specific antibodies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:43:39