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Titolo:
MEMBERS OF THE SYNDECAN FAMILY OF HEPARAN-SULFATE PROTEOGLYCANS ARE EXPRESSED IN DISTINCT CELL-SPECIFIC, TISSUE-SPECIFIC, AND DEVELOPMENT-SPECIFIC PATTERNS
Autore:
KIM CW; GOLDBERGER OA; GALLO RL; BERNFIELD M;
Indirizzi:
HARVARD UNIV,SCH MED,JOINT PROGRAM NEONATOL BOSTON MA 02115 HARVARD UNIV,SCH MED,JOINT PROGRAM NEONATOL BOSTON MA 02115 HARVARD UNIV,SCH MED,DEPT DERMATOL BOSTON MA 02115
Titolo Testata:
Molecular biology of the cell
fascicolo: 7, volume: 5, anno: 1994,
pagine: 797 - 805
SICI:
1059-1524(1994)5:7<797:MOTSFO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAMMARY EPITHELIAL-CELLS; FIBROBLAST GROWTH-FACTOR; INTEGRAL MEMBRANE PROTEOGLYCAN; HUMAN-LUNG FIBROBLASTS; SURFACE PROTEOGLYCAN; MOLECULAR-CLONING; TRANSIENT EXPRESSION; CORE PROTEINS; MOUSE EMBRYO; TUMOR-CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
67
Recensione:
Indirizzi per estratti:
Citazione:
C.W. Kim et al., "MEMBERS OF THE SYNDECAN FAMILY OF HEPARAN-SULFATE PROTEOGLYCANS ARE EXPRESSED IN DISTINCT CELL-SPECIFIC, TISSUE-SPECIFIC, AND DEVELOPMENT-SPECIFIC PATTERNS", Molecular biology of the cell, 5(7), 1994, pp. 797-805

Abstract

The syndecans are a gene family of four transmembrane heparan sulfateproteoglycans that bind, via their HS chains, diverse components of the cellular microenvironment. To evaluate the expression of the individual syndecans, we prepared cDNA probes to compare mRNA levels in various adult mouse tissues and cultured mouse cells representing various epithelial, fibroblastic, endothelial, and neural cell types and B cells at various stages of differentiation. We also prepared antibody probes to assess whether the extracellular domains of the individual syndecans are shed into the conditioned media of cultured cells. Our results show that all cells and tissues studied, except B-stem cells, express at least one syndecan family member; most cells and tissues expressmultiple syndecans. However, each syndecan family member is expressedselectively in cell-, tissue-, and development-specific patterns. Theextracellular domain of all syndecan family members is shed as an intact proteoglycan. Thus, most, if not all, cells acquire a distinctive repertoire of the four syndecan family members as they differentiate, resulting is selective patterns of expression that likely reflect distinct functions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 23:10:48