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Titolo:
BIOSYNTHESIS AND TRANSFORMATION OF TREMORGENIC INDOLE-DITERPENOIDS BYPENICILLIUM-PAXILLI AND ACREMONIUM-LOLII
Autore:
MANTLE PG; WEEDON CM;
Indirizzi:
UNIV LONDON IMPERIAL COLL SCI & TECHNOL,DEPT BIOCHEM LONDON SW7 2AY ENGLAND
Titolo Testata:
Phytochemistry
fascicolo: 5, volume: 36, anno: 1994,
pagine: 1209 - 1217
SICI:
0031-9422(1994)36:5<1209:BATOTI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
TALL-FESCUE; LOLITREM-B; INDOLODITERPENES; NEUROTOXINS; METABOLITES; PRECURSORS; MYCOTOXINS; PENITREMS; CRUSTOSUM; ENDOPHYTE;
Keywords:
PENICILLIUM PAXILLI; ACREMONIUM LOLII; PAXILLINE; TREMORGENIC MYCOTOXIN; BIOTRANSFORMATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
P.G. Mantle e C.M. Weedon, "BIOSYNTHESIS AND TRANSFORMATION OF TREMORGENIC INDOLE-DITERPENOIDS BYPENICILLIUM-PAXILLI AND ACREMONIUM-LOLII", Phytochemistry, 36(5), 1994, pp. 1209-1217

Abstract

Two novel metabolites of Penicillium paxilli were isolated and the structures determined, by mass spectrometry and H-1 NMR spectroscopy, as7 alpha-hydroxy-13-desoxy paxilline and 10 beta-hydroxy-13-desoxy paxilline. Chromatographically similar compounds were also recognized in fermentations of Acremonium lolii producing paxilline. Another indole-diterpenoid, 7 alpha-hydroxy paxilline, which was apparently not tremorgenic, was characterized from P. paxilli, and recognized chromatographically in A. lolii in which it was shown by radiolabelling experiments to arise from transformation of the tremorgenic mycotoxin paxilline. The significance of the new compounds in biosynthetic interrelationships between the various indole-diterpenoid metabolites of Acremonium, Aspergillus, Claviceps and Penicillium is discussed. Other notable aromatic amino acid-derived metabolites of A. lolii were tryptophol and tyrosol that were excreted from mycelia, the principal sterol of which was 5 alpha-ergosta-7,22E-dien-3 beta-ol.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 16:38:05