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Titolo:
CHRONIC BULLOUS DISEASE OF CHILDHOOD AND LINEAR IGA DISEASE OF ADULTSARE IGA1-MEDIATED DISEASES
Autore:
WOJNAROWSKA F; BHOGAL BS; BLACK MM;
Indirizzi:
CHURCHILL HOSP,DEPT DERMATOL OXFORD OX3 7LJ ENGLAND ST THOMAS HOSP,ST JOHNS INST DERMATOL,DEPT DERMATOPATHOL LONDON SE1 7EH ENGLAND
Titolo Testata:
British journal of dermatology
fascicolo: 2, volume: 131, anno: 1994,
pagine: 201 - 204
SICI:
0007-0963(1994)131:2<201:CBDOCA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
DERMATITIS-HERPETIFORMIS; IMMUNOGLOBULIN-A; SERUM LEVELS; DERMATOSIS; CHILDREN; IDENTIFICATION; NEPHROPATHY; DEPOSITION; ANTIBODIES; ANTIGENS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
F. Wojnarowska et al., "CHRONIC BULLOUS DISEASE OF CHILDHOOD AND LINEAR IGA DISEASE OF ADULTSARE IGA1-MEDIATED DISEASES", British journal of dermatology, 131(2), 1994, pp. 201-204

Abstract

Linear IgA disease is characterized by the presence of linear IgA deposits at the basement membrane zone of the skin, and in some cases by circulating basement membrane zone antibodies. The disease occurs in both adults and children, and is designated adult linear IgA disease inthe former and chronic bullous disease of childhood in the latter. The subclass distribution of the circulating and bound basement membranezone antibodies was studied in 32 children and eight adults. The results were compared with live dermatitis herpetiformis patients and fivenormal controls. The circulating antibodies (39 patients) and the cutaneous deposits (39 patients) were IgA1 in all 40 patients with linearIgA disease. The cutaneous deposits in dermatitis herpetiformis were also all IgA1, and no circulating antibodies were detected. The controls were all negative. This large series of children and adults with linear IgA disease demonstrates that the circulating and cutaneous basement membrane zone deposits are all IgA1, and suggests that linear IgA disease is an IgA1-mediated disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 05:52:22