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Titolo:
IN-VIVO ANTIINFLUENZA VIRUS ACTIVITY OF A ZINC-FINGER PEPTIDE
Autore:
JUDD AK; SANCHEZ A; BUCHER DJ; HUFFMAN JH; BAILEY K; SIDWELL RW;
Indirizzi:
SYNVAX,200 DAVEY GLEN RD,SUITE 514 BELMONT CA 94002 STANFORD UNIV,BECKMAN CTR,PROT & NUCLE ACID FACIL,SCH MED PALO ALTO CA 94304 NEW YORK MED COLL,DEPT MICROBIOL & IMMUNOL VALHALLA NY 10595 UTAH STATE UNIV,DEPT ANIM DAIRY & VET SCI LOGAN UT 84322
Titolo Testata:
Antimicrobial agents and chemotherapy
fascicolo: 3, volume: 41, anno: 1997,
pagine: 687 - 692
SICI:
0066-4804(1997)41:3<687:IAVAOA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MATRIX PROTEIN; A VIRUS; RNA; RIMANTADINE; SUSCEPTIBILITY; RECOGNITION; INHIBITION; RESISTANT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
A.K. Judd et al., "IN-VIVO ANTIINFLUENZA VIRUS ACTIVITY OF A ZINC-FINGER PEPTIDE", Antimicrobial agents and chemotherapy, 41(3), 1997, pp. 687-692

Abstract

Matrix protein (MI) is a major structural protein of influenza virus,and it inhibits its own polymerase, A 19-amino-acid peptide, corresponding to a zinc finger region of the M1 sequence of influenza virus strain A/PR/8/34 (HIN1), centered around amino acids 148 to 166, was synthesized, This peptide, designated peptide 6, represents a zinc fingerwhich includes a 7-amino-acid loop or finger and a 4-amino-acid tail at the carboxyl terminus, in addition to the 8 amino acids involved inthe coordination of Zn, Three experiments were run to evaluate the activity of peptide 6 on infections induced in mice by influenza A/PR/8/34 and A/Victoria/3/75 (H3N2) viruses. Intranasal (i.n.) treatment of the H1N1 virus infection with 30 or 60 mg/kg of body weight/day, threetimes daily for 5 days, beginning 4 h pre- or 8 h post-virus exposure, was effective in preventing death, reducing the arterial oxygen decline, and inhibiting lung consolidation, Virus titers in the lungs determined on day 5 were reduced by up to 1.5 log(10) in treated groups, but considerable variation in the titers of the recovered virus was seen, The H3N2 virus infection was treated i.n. with 30, 60, or 120 mg ofpeptide 6/kg/day by using the above-mentioned delayed initiation treatment schedule, and similar protection was seen, although lung virus titers were not reduced in the day-5 assay, Peptide 6 was well tolerated at doses up to 60 mg/kg/day, This zinc finger peptide may provide a new class of antivirals effective against influenza virus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/08/20 alle ore 20:46:13