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Titolo:
ALLOSTASIS, AMYGDALA, AND ANTICIPATORY ANGST
Autore:
SCHULKIN J; MCEWEN BS; GOLD PW;
Indirizzi:
NIMH,CLIN NEUROENDOCRINOL BRANCH,BEHAV NEUROSCI UNIT,BLDG 10,9000 ROCKVILLE PIKE BETHESDA MD 20892 ROCKEFELLER UNIV,DEPT NEUROENDOCRINOL NEW YORK NY 00000
Titolo Testata:
Neuroscience and biobehavioral reviews
fascicolo: 3, volume: 18, anno: 1994,
pagine: 385 - 396
SICI:
0149-7634(1994)18:3<385:AAAAA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; CENTRAL NUCLEUS LESIONS; GLUCOCORTICOID RECEPTOR IMMUNOREACTIVITY; MESSENGER-RNA EXPRESSION; ACOUSTIC STARTLE REFLEX; CENTRAL NERVOUS-SYSTEM; PARAVENTRICULAR NUCLEUS; IMMOBILIZATION-STRESS; RAT-BRAIN; BIOCHEMICAL MANIFESTATIONS;
Keywords:
AMYGDALA; ALLOSTASIS; PSYCHOPATHOLOGY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
166
Recensione:
Indirizzi per estratti:
Citazione:
J. Schulkin et al., "ALLOSTASIS, AMYGDALA, AND ANTICIPATORY ANGST", Neuroscience and biobehavioral reviews, 18(3), 1994, pp. 385-396

Abstract

Regions of the amygdala are involved in anticipation of negative events. Chronic anticipation of negative events leads to what we call allostatic load, or arousal pathology. Two hormones appear to be involved in arousal pathology; corticotropin-releasing hormone in the brain andglucocorticoids. We suggest that increases in corticotropin-releasinghormone, by stress or glucocorticoids, in the amygdala may have functional consequences for allostatic load. Whereas, corticotropin-releasing hormone in the parvocellular region of the paraventricular nucleus of the hypothalamus is decreased by glucocorticoids thereby under negative feedback and homeostatic control, the central nucleus of the amygdala is to some extent under positive feedback and is increased by glucocorticoids, and perhaps under allostatic control. The human and animal literature suggest that a variety of psychopathologies (e.g., melancholia) may be tied to neurohormonal signals activating regions of theamygdala.

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Documento generato il 26/01/20 alle ore 16:13:48