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Titolo:
LEPTOMENINGEAL METASTASES - ANALYSIS OF 31 PATIENTS WITH SUSTAINED OFF-THERAPY RESPONSE FOLLOWING COMBINED-MODALITY THERAPY
Autore:
SIEGAL T; LOSSOS A; PFEFFER MR;
Indirizzi:
HADASSAH UNIV HOSP,DEPT ONCOL,NEUROONCOL CLIN,POB 12000 IL-91120 JERUSALEM ISRAEL HADASSAH UNIV HOSP,DEPT NEUROL IL-91120 JERUSALEM ISRAEL
Titolo Testata:
Neurology
fascicolo: 8, volume: 44, anno: 1994,
pagine: 1463 - 1469
SICI:
0028-3878(1994)44:8<1463:LM-AO3>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-HODGKINS LYMPHOMA; NERVOUS-SYSTEM INVOLVEMENT; MENINGEAL CARCINOMATOSIS; NEOPLASTIC MENINGITIS; LUNG-CANCER; CHEMOTHERAPY; EXPERIENCE; DIAGNOSIS; BREAST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
T. Siegal et al., "LEPTOMENINGEAL METASTASES - ANALYSIS OF 31 PATIENTS WITH SUSTAINED OFF-THERAPY RESPONSE FOLLOWING COMBINED-MODALITY THERAPY", Neurology, 44(8), 1994, pp. 1463-1469

Abstract

Thirty-one (23%) of 137 patients treated for leptomeningeal metastases (LM) achieved a sustained off-therapy response of at least 6 months'duration following treatment by a standard protocol. Of the 31 patients, equal distribution was found among various tumors: lymphoma, 13/44(29%); breast carcinoma, 10/51 (20%); and other tumors, 8/42 (19%). Neuroimaging of the neuraxis disclosed subarachnoid deposits in 70%, with unexpected findings in 55%. At withdrawal of therapy, all 13 patients with lymphomas had achieved a complete response, and for those withthe other tumors, 61% had a partial response. Off-therapy relapse wasunrelated to the type of attained response and occurred in nine patients (29%) after a median time of 12 months. Five patients obtained a second prolonged response, mainly by systemic therapy. All eight patients who received only systemic therapy for their LM responded to treatment, four with a complete response. All others received both systemic and intra-CSF treatment and maintained a systemic response. Delayed complications occurred in 58%, with leukoencephalopathy equally affecting patients exposed and patients not exposed to cranial irradiation. The median survival of the whole group was 23 months. We conclude that in LM (lymphomas excluded), a partial response is compatible with a prolonged off-therapy response. Since LM may respond to systemic treatment, the role of intra-CSF therapy, with its associated complications, deserves a prospective reevaluation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 01:12:21