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Titolo:
EVIDENCE THAT APOLIPOPROTEIN(A) PHENOTYPE IS A RISK FACTOR FOR CORONARY-ARTERY DISEASE IN MEN LESS-THAN-OR-EQUAL-TO-55 YEARS OF AGE
Autore:
PARLAVECCHIA M; PANCALDI A; TARAMELLI R; VALSANIA P; GALLI L; POZZA G; CHIERCHIA S; RUOTOLO G;
Indirizzi:
UNIV MILAN,SCI INST H SAN RAFFAELE,DEPT CARDIOL,LIPOPROT METAB & ATHEROSCLEROSIS LAB I-20132 MILAN ITALY UNIV MILAN,SCI INST H SAN RAFFAELE,DEPT CARDIOL,LIPOPROT METAB & ATHEROSCLEROSIS LAB I-20132 MILAN ITALY UNIV MILAN,SCI INST H SAN RAFFAELE,DEPT GENET MILAN ITALY UNIV MILAN,SCI INST H SAN RAFFAELE,DEPT EPIDEMIOL & BIOSTAT MILAN ITALY
Titolo Testata:
The American journal of cardiology
fascicolo: 4, volume: 74, anno: 1994,
pagine: 346 - 351
SICI:
0002-9149(1994)74:4<346:ETAPIA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSITY LIPOPROTEIN CHOLESTEROL; HEART-DISEASE; MYOCARDIAL-INFARCTION; LP(A) CONCENTRATIONS; PLASMA; ASSOCIATION; ISOFORMS; POPULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
M. Parlavecchia et al., "EVIDENCE THAT APOLIPOPROTEIN(A) PHENOTYPE IS A RISK FACTOR FOR CORONARY-ARTERY DISEASE IN MEN LESS-THAN-OR-EQUAL-TO-55 YEARS OF AGE", The American journal of cardiology, 74(4), 1994, pp. 346-351

Abstract

Whereas the importance of plasma lipoprotein(a) [Lp(a)] levels as a risk factor for premature coronary artery disease (CAD) is certain, it is not clear if the apolipoprotein(a) [apo(a)] phenotype plays an additional and independent role. To investigate the possible effect of apo(a) phenotype on premature CAD (in patients <55 years of age), plasma Lp(a) concentrations, the apo(a) phenotypes, and their relation with many recognized CAD risk factors were examined in 96 nondiabetic male patients with angiographically defined CAD and in 83 age-matched male control subjects with no angiographic evidence of CAD. Results demonstrate that patients with premature CAD are characterized by higher Lp(a)levels (24 +/- 21 vs 17 +/- 15 mg/dl, p <0.01) and a higher frequencyof S2 phenotype (32% vs 15%, p <0.01). Patients with an S2 phenotype exhibited significantly higher plasma Lp(a) concentrations than control subjects with the same isoform (37 +/- 22 vs 22 +/- 17 mg/dl, p <0.05). A significant correlation was found between ape B and Lp(a) levelsin patients with an 32 phenotype. In addition, patients had a low frequency of S1 and S4, and a high frequency of double-band phenotypes ofapo(a). Multivariate analysis did not demonstrate an independent rolefor apo(a) phenotype as a risk factor for premature CAD. In conclusion, CAD patients <55 years of age have a very different pattern of apo(a) phenotypes than subjects with no angiographic evidence of CAD; thisstudy confirms the hypothesis that apo(a) phenotype may play an additional role in the etiology of premature CAD.

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Documento generato il 18/09/20 alle ore 16:33:49