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Titolo:
CLONING OF FELINE P53 TUMOR-SUPPRESSOR GENE AND ITS ABERRATION IN HEMATOPOIETIC TUMORS
Autore:
OKUDA M; UMEDA A; SAKAI T; OHASHI T; MOMOI Y; YOUN HY; WATARI T; GOITSUKA R; TSUJIMOTO H; HASEGAWA A;
Indirizzi:
UNIV TOKYO,FAC AGR,DEPT VET INTERNAL MED TOKYO 113 JAPAN
Titolo Testata:
International journal of cancer
fascicolo: 4, volume: 58, anno: 1994,
pagine: 602 - 607
SICI:
0020-7136(1994)58:4<602:COFPTG>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL TUMORS; NUCLEOTIDE-SEQUENCE; NUCLEAR ONCOPROTEIN; MOLECULAR-CLONING; MYC GENE; MUTATIONS; ANTIGEN; EXPRESSION; LINE; TRANSFORMATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
M. Okuda et al., "CLONING OF FELINE P53 TUMOR-SUPPRESSOR GENE AND ITS ABERRATION IN HEMATOPOIETIC TUMORS", International journal of cancer, 58(4), 1994, pp. 602-607

Abstract

Alterations of the p53 tumor-suppressor gene have been observed in a variety of human and mouse tumors. For investigation of the role of this gene in tumors of cats, feline p53 cDNA was molecularly cloned froma feline lymph-node cDNA library. The cloned cDNA (FF53) contained the whole open reading frame of p53 gene encoding 386 amino acids. The amino-acid sequence of the feline p53 gene showed 82.1% and 74.9% similarities with those of the human and mouse counterparts, respectively, and had structural characteristics in common with the p53 genes of several other species. Aberrations of the p53 gene were investigated by RT-PCR and single-strand conformation polymorphism analyses. Of 10 primary hematopoietic tumors and 3 lymphoma cell lines examined, one lymphoma and one lymphoma cell line had a point mutation of the p53 gene, resulting in single amino-acid substitutions. (C) 1994 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 21:43:24