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Titolo:
IDENTIFICATION OF A GLUTAMATE ASPARTATE TRANSPORTER IN THE RAT COCHLEA/
Autore:
LI HS; NIEDZIELSKI AS; BEISEL KW; HIEL H; WENTHOLD RJ; MORLEY BJ;
Indirizzi:
BOYS TOWN NATL RES HOSP,55 N 30TH ST OMAHA NE 68131 BOYS TOWN NATL RES HOSP OMAHA NE 68131 NATL INST DEAFNESS & COMMUN DISORDERS,NEUROCHEM LAB BETHESDA MD 00000
Titolo Testata:
Hearing research
fascicolo: 2, volume: 78, anno: 1994,
pagine: 235 - 242
SICI:
0378-5955(1994)78:2<235:IOAGAT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG COCHLEA; POTASSIUM-INDUCED RELEASE; SPIRAL GANGLION NEURONS; RECEPTOR MESSENGER-RNAS; AMINO-ACID CONTENT; KAINIC ACID; AUDITORY-NERVE; HAIR-CELLS; GLUTAMATE TRANSPORTER; SOUND STIMULATION;
Keywords:
GLUTAMATE TRANSPORTER; COCHLEA; CDNA; POLYMERASE CHAIN REACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
H.S. Li et al., "IDENTIFICATION OF A GLUTAMATE ASPARTATE TRANSPORTER IN THE RAT COCHLEA/", Hearing research, 78(2), 1994, pp. 235-242

Abstract

The neurotransmitter at the synapses between hair cells and spiral ganglion cells in the cochlea is probably L-glutamate or a similar excitatory amino acid. Glutamate uptake by nerve terminals and glial cells is an important component of neurotransmission at glutamatergic synapses of the central nervous system, for providing a reservoir of transmitter or transmitter precursors and the termination of the released glutamate. Hair cell synapses are not surrounded by glial cells, therefore, the uptake mechanism for glutamate in the cochlea may be unique, cDNA was synthesized from total RNA isolated separately from the rat organ of Corti, spiral ganglia, and lateral wall tissues. The expression of a glutamate/aspartate transporter (GLAST) was detected by DNA amplification with the polymerase chain reaction. The other two members of glutamate transporters in this family were not detected by this method. A partial cDNA encoding to GLAST was identified by sequence analysisin a rat cochlear cDNA library. Data concerning the expression and the molecular structure of the glutamate transporter GLAST in the cochlea may provide important information regarding the neurotransmission process at the hair cell-afferent synapses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 20:46:19