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Titolo:
CONJUGATES OF DENDRITIC CELLS AND MEMORY T-LYMPHOCYTES FROM SKIN FACILITATE PRODUCTIVE INFECTION WITH HIV-1
Autore:
POPE M; BETJES MGH; ROMANI N; HIRMAND H; CAMERON PU; HOFFMAN L; GEZELTER S; SCHULER G; STEINMAN RM;
Indirizzi:
ROCKEFELLER UNIV,CELLULAR PHYSIOL & IMMUNOL LAB NEW YORK NY 10021 VRIJE UNIV AMSTERDAM,DEPT CELL BIOL 1081 BT AMSTERDAM NETHERLANDS CORNELL UNIV,COLL MED,DIV PLAST SURG NEW YORK NY 10021 INNSBRUCK UNIV,DEPT DERMATOL A-6020 INNSBRUCK AUSTRIA
Titolo Testata:
Cell
fascicolo: 3, volume: 78, anno: 1994,
pagine: 389 - 398
SICI:
0092-8674(1994)78:3<389:CODCAM>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; EPIDERMAL LANGERHANS CELLS; FEMALE RHESUS MACAQUES; IMMUNE-RESPONSES; ADHESION MOLECULE; LYMPHOID-TISSUE; GENITAL-TRACT; HUMAN BLOOD; AIDS; LYMPHADENOPATHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
M. Pope et al., "CONJUGATES OF DENDRITIC CELLS AND MEMORY T-LYMPHOCYTES FROM SKIN FACILITATE PRODUCTIVE INFECTION WITH HIV-1", Cell, 78(3), 1994, pp. 389-398

Abstract

Experimentally, a productive infection with HIV-1 requires that virusbe administered to T cells that are activated by mitogens. We describe a productive milieu for HIV-1 within the confines of normal skin that does not require standard stimuli. The milieu consists of dendritic cells and T cells that emigrate from skin and produce distinctive stable, nonproliferating conjugates. These conjugates, upon exposure to each of seven different HIV-1 isolates, begin to release high levels of virus progeny within 4 days. Numerous infected syncytia, comprised of both dendritic and T cells, rapidly develop. We propose that conjugates of dendritic cells and T cells, as found in the external linings of organs involved in sexual transmission of HIV-1, represent an important site for the productive phase of HIV-1 infection. Because the affected T cells carry the memory phenotype, this site additionally providesa mechanism for the chronic depletion of CD4(+) memory cells in HIV-1disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:25:41