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Titolo:
SEARCH FOR A SUSCEPTIBILITY LOCUS TO TARDIVE-DYSKINESIA
Autore:
INADA T; DOBASHI I; SUGITA T; INAGAKI A; KITAO Y; MATSUDA G; KATO S; TAKANO T; YAGI G; ASAI M;
Indirizzi:
NIMH,NATL CTR NEUROL & PSYCHIAT,1-7-3 KOHNODAI ICHIKAWA CHIBA 272 JAPAN KEIO UNIV,SCH MED,DEPT MICROBIOL TOKYO 160 JAPAN YAMANASHI PREFECTURAL KITA HOSP YAMANASHI JAPAN NATL KOHNODAI HOSP,NATL CTR NEUROL & PSYCHIAT CHIBA JAPAN NATL PSYCHIAT INST SHIMOFUSA CHIBA JAPAN KEIO UNIV,SCH MED,DEPT NEUROPSYCHIAT TOKYO JAPAN
Titolo Testata:
Human psychopharmacology
fascicolo: 1, volume: 12, anno: 1997,
pagine: 35 - 39
SICI:
0885-6222(1997)12:1<35:SFASLT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR; POLYMORPHISM; DOPAMINE-D2;
Keywords:
TARDIVE DYSKINESIA; GENE; POLYMORPHISM; DRD2; DRD3; DOPAMINE TRANSPORTER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
8
Recensione:
Indirizzi per estratti:
Citazione:
T. Inada et al., "SEARCH FOR A SUSCEPTIBILITY LOCUS TO TARDIVE-DYSKINESIA", Human psychopharmacology, 12(1), 1997, pp. 35-39

Abstract

In order to find a genetic marker for vulnerability to tardive dyskinesia (TD), we looked for an association between vulnerability to TD and polymorphic sites in the gene loci encoding the dopamine D2 receptor(Nco I site), the dopamine D3 receptor (Bal I site), and the dopaminetransporter (40-bp, tandem repeat polymorphism). No significant difference was observed in the allele and genotype frequencies of any of the polymorphic sites examined, when comparing psychiatric patients who were specifically vulnerable to TD (n = 49) and those who were not (n = 56). These results suggest that the polymorphic gene loci examined in the present study are unlikely to be of major aetiologic importance in the development of TD.

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Documento generato il 31/05/20 alle ore 12:31:26