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Titolo:
CLOZAPINE DRUG-DRUG INTERACTIONS - A REVIEW OF THE LITERATURE
Autore:
EDGE SC; MARKOWITZ JS; DEVANE CL;
Indirizzi:
MED UNIV S CAROLINA,INST PSYCHIAT,DEPT PHARM PRACTICE,171 ASHLEY AVE CHARLESTON SC 29465 MED UNIV S CAROLINA,INST PSYCHIAT,DEPT PHARM PRACTICE CHARLESTON SC 29465 MED UNIV S CAROLINA,INST PSYCHIAT,DEPT PSYCHIAT & BEHAV SCI CHARLESTON SC 29465
Titolo Testata:
Human psychopharmacology
fascicolo: 1, volume: 12, anno: 1997,
pagine: 5 - 20
SICI:
0885-6222(1997)12:1<5:CDI-AR>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROLEPTIC MALIGNANT SYNDROME; PHARMACOKINETIC INTERACTION; N-DESMETHYLCLOZAPINE; ANTIPSYCHOTIC AGENT; PLASMA-LEVELS; METABOLISM; SCHIZOPHRENIA; CARBAMAZEPINE; LITHIUM; FLUVOXAMINE;
Keywords:
CLOZAPINE; DRUG INTERACTION; POLYPHARMACY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
79
Recensione:
Indirizzi per estratti:
Citazione:
S.C. Edge et al., "CLOZAPINE DRUG-DRUG INTERACTIONS - A REVIEW OF THE LITERATURE", Human psychopharmacology, 12(1), 1997, pp. 5-20

Abstract

Clozapine is often used in combination with other medications. To date, there has been no comprehensive review of drug-drug interactions involving clozapine. This review summarizes published reports of suspected drug-drug interactions, and assesses their clinical significance. Acomputerized search was conducted using MEDLINE (1975-1996) to retrieve all reports of adverse events associated with the concurrent use ofclozapine and other agents. Forty-three reports involving 19 different drugs were evaluated. Clozapine appeared to be involved in pharmacokinetic and pharmacodynamic interactions when prescribed concurrently with most major classes of therapeutic agents. In general, the additionof other medications with similar pharmacological effects or side-effects to clozapine may enhance these effects in an additive or possiblysynergistic manner. The selective serotonin reuptake inhibitor fluvoxamine was involved in the most thoroughly documented pharmacokinetic interactions, while a number of reports were found implicating various benzodiazepines in apparent pharmacodynamic interactions. No clozapine-drug combination is absolutely contraindicated, but some members of agiven therapeutic class may pose less risk than others when used concurrently with clozapine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:57:36