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Titolo:
EXPRESSION OF BCL-2 PROTEIN AND FAS ANTIGEN IN NON-HODGKINS-LYMPHOMAS
Autore:
KONDO E; YOSHINO T; YAMADORI I; MATSUO Y; KAWASAKI N; MINOWADA J; AKAGI T;
Indirizzi:
OKAYAMA UNIV,SCH MED,DEPT PATHOL,SHIKATA CHO 2-5-1 OKAYAMA 700 JAPAN OKAYAMA UNIV,SCH MED,DEPT PATHOL OKAYAMA 700 JAPAN HAYASHIBARA BIOCHEM LABS INC,FUJISAKI CELL CTR OKAYAMA JAPAN
Titolo Testata:
The American journal of pathology
fascicolo: 2, volume: 145, anno: 1994,
pagine: 330 - 337
SICI:
0002-9440(1994)145:2<330:EOBPAF>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; CELL-SURFACE ANTIGEN; BREAKPOINT-CLUSTER REGION; B-CELLS; MONOCLONAL-ANTIBODY; MOLECULAR-CLONING; DEATH; APOPTOSIS; RECEPTOR; SURVIVAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
E. Kondo et al., "EXPRESSION OF BCL-2 PROTEIN AND FAS ANTIGEN IN NON-HODGKINS-LYMPHOMAS", The American journal of pathology, 145(2), 1994, pp. 330-337

Abstract

Expression of Bcl-2 protein and Fas antigens was analyzed in 12 casesof follicular lymphoma and 32 cases of diffuse lymphoma, including 22B-cell and 10 T-cell lymphomas. It was shown that 75% of follicular lymphomas had clear expression of both Bcl-2 protein and Fas antigen. Thus, follicular lymphomas may have a growth advantage due to their high expression of Bcl-2 protein, which tended to impede apoptosis mediated by Fas antigen On the other hand, diffuse lymphomas showed various patterns; 28% were double positive, 16% were only Bcl-2 protein-positive, 28% were only Fas antigen-positive, and 28% were double negative or equivocal. Cytocidal assay of seven leukemia/lymphoma cell lines using anti-human Fas monoclonal antibody revealed that overexpression of Bcl-2 protein tended to impede apoptosis mediated by Fas antigen. However, this inhibitory effect of Bcl-2 protein was incomplete and its effect might be dependent upon cell type

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 16:11:41