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Titolo:
TRANSPLANTATION OF T-CELL-MEDIATED, LYMPHORETICULAR DISEASE FROM THE SCURFY (SF) MOUSE
Autore:
GODFREY VL; ROUSE BT; WILKINSON JE;
Indirizzi:
OAK RIDGE NATL LAB,DIV BIOL,POB 2009 OAK RIDGE TN 37831 UNIV TENNESSEE,COLL VET MED KNOXVILLE TN 00000
Titolo Testata:
The American journal of pathology
fascicolo: 2, volume: 145, anno: 1994,
pagine: 281 - 286
SICI:
0002-9440(1994)145:2<281:TOTLDF>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
VERSUS-HOST DISEASE; MINOR HISTOCOMPATIBILITY ANTIGENS; TRANSGENIC MICE; LPR; LYMPHOPROLIFERATION; MODEL;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
V.L. Godfrey et al., "TRANSPLANTATION OF T-CELL-MEDIATED, LYMPHORETICULAR DISEASE FROM THE SCURFY (SF) MOUSE", The American journal of pathology, 145(2), 1994, pp. 281-286

Abstract

The X-linked mutation, scurfy (sf), causes a fatal lymphoreticular disease characterized by runting, lymphadenopathy, splenomegaly, hypergammaglobulinemia, exfoliative dermatitis, Coombs'-positive anemia, and death by 24 days of age. T lymphocytes are required to mediate this syndrome as shown by a total absence of disease in mice bred to be scurfy and nude (sf/Y; nu/nu). The scurfy phenotype is not transmitted by sf/Y bone marrow transplants, though cells of scurfy origin do reconstitute all lymphoid organs in the recipient mouse. These data suggest that scurfy disease results from an abnormal T cell development process and not from an intrinsic stem cell defect. We therefore tested the ability of transplanted scurfy thymuses to transmit scurfy disease to congenic euthymic mice, to athymic (nude) mice, and to severe combined immunodeficiency (SCID) mice. Euthymic recipients of sf/Y thymic graftsremained clinically normal as did all SCID and nude recipients of normal thymus transplants. Morphological lesions similar to those found in scurfy mice occurred in all H-2- compatible nude and SCID recipientsof sf/Y thymic grafts. Intraperitoneal injections of scurfy thymocytes, splenocytes, and lymph node cells also transmitted the scurfy phenotype to H-2-compatible nude mice and SCID mice. Our findings indicate that scurfy, disease cas be transmitted to T cell-deficient mice by engraftment of scurfy T cells, but that pathogenic scurfy T cell activities can be inhibited (or prevented)) ill immunocompetent recipient mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:32:10