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Titolo:
NEUROPATHY TARGET ESTERASE INHIBITION BY ORGANOPHOSPHORUS ESTERS IN HUMAN NEUROBLASTOMA-CELLS
Autore:
EHRICH M; CORRELL L; VERONESI B;
Indirizzi:
VIRGINIA MARYLAND REG COLL VET MED BLACKSBURG VA 24061 US EPA,DIV NEUROTOXICOL RES TRIANGLE PK NC 27711
Titolo Testata:
Neurotoxicology
fascicolo: 2, volume: 15, anno: 1994,
pagine: 309 - 313
SICI:
0161-813X(1994)15:2<309:NTEIBO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED DELAYED NEUROTOXICITY; ANTICHOLINESTERASE ACTIVITY; HUMAN-LYMPHOCYTES; NERVE AGENTS; INVITRO; CULTURES;
Keywords:
HUMAN NEUROBLASTOMA; SH-SY5Y CELLS; NEUROPATHY TARGET ESTERASE; ORGANOPHOSPHORUS-INDUCED DELAYED NEUROPATHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
M. Ehrich et al., "NEUROPATHY TARGET ESTERASE INHIBITION BY ORGANOPHOSPHORUS ESTERS IN HUMAN NEUROBLASTOMA-CELLS", Neurotoxicology, 15(2), 1994, pp. 309-313

Abstract

Certain organophosphorus compounds (OPs) produce a delayed neuropathy(OPIDN) in man and some animal species. Capability to cause OPIDN is generally predicted in animal models by early and irreversible inhibition of neuropathy target esterase (NTE, neurotoxic esterase). In this study, NTE inhibition in response to OP exposure was examined in cell culture, using the human SH-SY5Y neuroblastoma cell line. Cells were exposed for 1 hr to equimolar (1 x 10(-5) M) concentrations of 6 OPs associated with OPIDN in vivo (including 2 protoxicants and 4 active (-P= O) toxicants), and 8 OPs that do not produce delayed neuropathy in animal models (including 5 protoxicants and 3 -P = O compounds). The -P = O compounds that cause OPIDN in animal models inhibited NTE > 60% at the test concentration; -P = O compounds that do not cause OPIDN inanimal models inhibited NTE < 30%. Protoxicants did not inhibit NTE at the test concentration, reflecting their limited metabolism in the human cell line. These results indicate that human neuroblastoma cells have potential use in the initial screening of bioactive OPs with capability for causing OPIDN. (C) 1994 Intox Press, Inc.

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Documento generato il 23/09/20 alle ore 13:15:54