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Titolo:
WNT-1-DEPENDENT REGULATION OF LOCAL E-CADHERIN AND ALPHA-N-CATENIN EXPRESSION IN THE EMBRYONIC MOUSE-BRAIN
Autore:
SHIMAMURA K; HIRANO S; MCMAHON AP; TAKEICHI M;
Indirizzi:
KYOTO UNIV,FAC SCI,DEPT BIOPHYS,SAKYO KU KYOTO 60601 JAPAN KYOTO UNIV,FAC SCI,DEPT BIOPHYS,SAKYO KU KYOTO 60601 JAPAN NATL INST BASIC BIOL,DIV MOLEC NEUROBIOL MYODAIJI OSAKA 444 JAPAN HARVARD UNIV,BIOL LABS,DEPT CELLULAR & DEV BIOL CAMBRIDGE MA 02138
Titolo Testata:
Development
fascicolo: 8, volume: 120, anno: 1994,
pagine: 2225 - 2234
SICI:
0950-1991(1994)120:8<2225:WROLEA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLARITY GENE ARMADILLO; MAMMARY ONCOGENE INT-1; BETA-CATENIN; NUCLEOTIDE-SEQUENCE; ECTOPIC EXPRESSION; DROSOPHILA HOMOLOG; WINGLESS PROTEIN; XENOPUS EMBRYOS; CELL-LINE; BODY AXIS;
Keywords:
E-CADHERIN; ALPHA-N-CATENIN; WNT-1; ROOF PLATE; BRAIN MORPHOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
K. Shimamura et al., "WNT-1-DEPENDENT REGULATION OF LOCAL E-CADHERIN AND ALPHA-N-CATENIN EXPRESSION IN THE EMBRYONIC MOUSE-BRAIN", Development, 120(8), 1994, pp. 2225-2234

Abstract

E-cadherin is transiently expressed in local regions of the embryonicmouse brain, which include several patchy areas on the mesencephalon and diencephalon and their roof plate and part of cerebellar rudiments. In the present study, we compared this E-cadherin expression with that of Wnt-1, which occurs in specific zones in the embryonic brain, and found certain spatiotemporal relations between them: Wnt-1 expression tended to run parallel or overlap with peripheries of the E-cadherin-positive areas. For example, in the dorsal midline, Wnt-1 was expressed at the middle of the roof plate, while E-cadherin was absent in themiddle zone but detected in two arrays of marginal roof plate cells. Furthermore, alpha N-catenin, a cadherin-associated protein, was foundto occur at the roof plate of the mesencephalon and diencephalon, coinciding with Wnt-1 expression. The expression of these molecules was then studied in two alleles of the Wnt-1 mutation, Wnt-1(SW) and Wnt-1(neo). In mice homozygous for these mutant genes, E-cadherin expressionin the roof plate was up-regulated; the middle E-cadherin-negative zone disappeared. Moreover, E-cadherin expression in the roof plate began earlier in the mutant mice than in wild-type mice. On the contrary, alpha N-catenin expression in the dorsal midline was suppressed in these mutants. These changes in cadherin and catenin expression occurred at the level of mRNA expression. These results suggest that the Wnt-1 signal is, either directly or indirectly, involved in the regulation of expression of E-cadherin and alpha N-catenin in restricted regions of the embryonic brain. This mechanism may contribute to the patterningof the expression of these adhesion-related proteins in the embryonicbrain.

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Documento generato il 05/12/20 alle ore 02:04:41