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Titolo:
SPECTROFLUOROMETRIC ANALYSIS OF CEFUROXIME IN PHARMACEUTICAL DOSAGE FORMS
Autore:
MURILLO JA; LEMUS JM; GARCIA LF;
Indirizzi:
UNIV CASTILLA LA MANCHA,DEPT ANALYT CHEM & FOOD TECHNOL E-13071 CIUDAD REAL SPAIN
Titolo Testata:
Journal of pharmaceutical and biomedical analysis
fascicolo: 7, volume: 12, anno: 1994,
pagine: 875 - 881
SICI:
0731-7085(1994)12:7<875:SAOCIP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLUOROMETRIC ANALYSIS; CEPHALOSPORIN;
Keywords:
CEFUROXIME; SPECTROFLUOROMETRY; PHARMACEUTICAL DOSAGE FORMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Murillo et al., "SPECTROFLUOROMETRIC ANALYSIS OF CEFUROXIME IN PHARMACEUTICAL DOSAGE FORMS", Journal of pharmaceutical and biomedical analysis, 12(7), 1994, pp. 875-881

Abstract

A fluorimetric method has been developed for the quantitative analysis of cefuroxime, based upon the formation of a fluorescent derivative formed by alkaline hydrolysis with 1.0 M sodium hydroxide and heating at 100-degrees-C for 60 min. The fluorescent product gave excitation and emission maxima at 380 and 436 nm, respectively. The method was performed in aqueous solution adjusted to pH 10.5 by addition of phosphate buffer solution. The calibration curve was found to be linear in therange of concentrations 0.050-1.70 mug ml-1. The lower limit of detection was 1.0 X 10(-2) mug ml-1. The method was applied to authentic pharmaceutical preparations containing cefuroxime sodium or cefuroxime axetil, the 1-(acetyloxy) ethyl ester of the drug, and was found to be satisfactory. Cefuroxime sodium was also determined in physiological solutions used to prepare intravenous infusions of this antibiotic.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:46:20